Utilization of Multiparametric MRI of Prostate in Patients under Consideration for or Already in Active Surveillance: Correlation with Imaging Guided Target Biopsy

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dc.contributor.authorYu, Jinxingen
dc.contributor.authorFulcher, Ann S.en
dc.contributor.authorWinks, Sarahen
dc.contributor.authorTurner, Mary A.en
dc.contributor.authorBehl, Williamen
dc.contributor.authorWare, Anna Leeen
dc.contributor.authorMukhopadhyay, Nitai D.en
dc.contributor.authorKim, Candiceen
dc.contributor.authorJackson, Christopheren
dc.contributor.authorBajaj, Harnek S.en
dc.contributor.authorHampton, Lance J.en
dc.contributor.departmentBiological Sciencesen
dc.date.accessioned2020-06-30T16:40:34Zen
dc.date.available2020-06-30T16:40:34Zen
dc.date.issued2020-06-29en
dc.date.updated2020-06-30T16:28:46Zen
dc.description.abstractThis study sought to assess the value of multiparametric magnetic resonance image (mp-MRI) in patients with a prostate cancer (PCa) Gleason score of 6 or less under consideration for or already in active surveillance and to determine the rate of upgrading by target biopsy. Three hundred and fifty-four consecutive men with an initial transrectal ultrasound-guided (TRUS) biopsy-confirmed PCa Gleason score of 6 or less under clinical consideration for or already in active surveillance underwent mp-MRI and were retrospectively reviewed. One hundred and nineteen of 354 patients had cancer-suspicious regions (CSRs) at mp-MRI. Each CSR was assigned a Prostate Imaging Reporting and Data System (PI-RADS) score based on PI-RADS v2. One hundred and eight of 119 patients underwent confirmatory imaging-guided biopsy for CSRs. Pathology results including Gleason score (GS) and percentage of specimens positive for PCa were recorded. Associations between PI-RADS scores and findings at target biopsy were evaluated using logistic regression. At target biopsy, 81 of 108 patients had PCa (75%). Among them, 77 patients had upgrading (22%, 77 of 354 patients). One hundred and forty-six CSRs in 108 patients had PI-RADS 3 <i>n</i> = 28, 4 <i>n</i> = 66, and 5 <i>n</i> = 52. The upgraded rate for each category of CSR was for PI-RADS 3 (5 of 28, 18%), 4 (47 of 66, 71%) and 5 (49 of 52, 94%). Using logistic regression analysis, differences in PI-RADS scores from 3 to 5 are significantly associated with the probability of disease upgrade (20%, 73%, and 96% for PI-RADS score of 3, 4, and 5, respectively). Adding mp-MRI to patients under consideration for or already in active surveillance helps to identify undiagnosed PCa of a higher GS or higher volume resulting in upgrading in 22%.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationYu, J.; Fulcher, A.S.; Winks, S.; Turner, M.A.; Behl, W.; Ware, A.L.; Mukhopadhyay, N.D.; Kim, C.; Jackson, C.; Bajaj, H.S.; Hampton, L.J. Utilization of Multiparametric MRI of Prostate in Patients under Consideration for or Already in Active Surveillance: Correlation with Imaging Guided Target Biopsy. Diagnostics 2020, 10, 441.en
dc.identifier.doihttps://doi.org/10.3390/diagnostics10070441en
dc.identifier.urihttp://hdl.handle.net/10919/99199en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectprostate canceren
dc.subjectactive surveillanceen
dc.subjectmultiparametric MRIen
dc.subjectPI-RADS scoreen
dc.subjectimaging-guided target prostate biopsyen
dc.titleUtilization of Multiparametric MRI of Prostate in Patients under Consideration for or Already in Active Surveillance: Correlation with Imaging Guided Target Biopsyen
dc.title.serialDiagnosticsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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