Case Report of Seronegative Cancer-Associated Retinopathy in a Patient with Small Cell Lung Carcinoma

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dc.contributor.authorThomas, Milesen
dc.contributor.authorBenfield, Johnen
dc.contributor.authorMorales, Joshuaen
dc.date.accessioned2024-08-30T19:10:06Zen
dc.date.available2024-08-30T19:10:06Zen
dc.date.issued2023-09-04en
dc.description.abstractCancer-associated retinopathy (CAR) is a rare paraneoplastic syndrome characterized by autoimmune destruction of photoreceptor cells. It is associated with several tumor types, including small cell lung carcinoma (SCLC). Corticosteroids have been the mainstay treatment for CAR, although no therapeutic standard has truly been established. A 66-year-old female with significant smoking history and age-related macular degeneration (ARMD) presented with rapidly declining bilateral visual acuity. Ophthalmologic examination findings appeared consistent with the known diagnosis of ARMD but did not otherwise present a clear alternative etiology. Imaging with a computed tomography (CT) scan revealed a right hilar mass which was confirmed to be limited stage SCLC based on a subsequent biopsy and further imaging with a positron emission tomography/computed tomography (PET/CT) scan. Antibody testing was negative for anti-recoverin antibodies. The patient experienced a complete response to chemoradiation with cisplatin and etoposide; however, her ocular symptoms did not respond to a combined treatment approach with corticosteroids, plasmapheresis, and intravenous immunoglobulin (IVIG). While CAR represents a rare condition in SCLC, cases that are seronegative for anti-recoverin are even less common. Further, the diagnosis of CAR by ophthalmologic examination may be more challenging in patients with pre-existing ocular diseases, such as macular degeneration. Clinicians should have suspicion for paraneoplastic blindness in patients with known risk factors for malignancy, whose ocular symptoms are inconsistent with exam findings.en
dc.description.versionPublished versionen
dc.format.extentPages 791-796en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1159/000531624en
dc.identifier.eissn1662-6575en
dc.identifier.issn1662-6575en
dc.identifier.issue1en
dc.identifier.orcidMorales, Joshua [0009-0003-3708-5298]en
dc.identifier.otherPMC10601748en
dc.identifier.other531624 (PII)en
dc.identifier.pmid37900796en
dc.identifier.urihttps://hdl.handle.net/10919/121040en
dc.identifier.volume16en
dc.language.isoenen
dc.publisherKargeren
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/37900796en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectCancer-associated retinopathyen
dc.subjectParaneoplastic syndromeen
dc.subjectSmall cell lung canceren
dc.titleCase Report of Seronegative Cancer-Associated Retinopathy in a Patient with Small Cell Lung Carcinomaen
dc.title.serialCase Reports in Oncologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherJournal Articleen
dcterms.dateAccepted2023-06-13en
pubs.organisational-groupVirginia Techen
pubs.organisational-groupVirginia Tech/VT Carilion School of Medicineen
pubs.organisational-groupVirginia Tech/VT Carilion School of Medicine/Internal Medicineen
pubs.organisational-groupVirginia Tech/VT Carilion School of Medicine/Internal Medicine/Oncologyen

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