Transplacental transmission of a North American isolate of Leishmania infantum in an experimentally infected beagle

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dc.contributor.authorRosypal, A. C.en
dc.contributor.authorTroy, Gregory C.en
dc.contributor.authorZajac, Anne M.en
dc.contributor.authorFrank, G.en
dc.contributor.authorLindsay, David S.en
dc.date.accessed2014-06-16en
dc.date.accessioned2014-06-20T14:13:23Zen
dc.date.available2014-06-20T14:13:23Zen
dc.date.issued2005-08en
dc.description.abstractLeishmania infantum, an etiologic agent of zoonotic visceral leishmaniasis, is widespread among foxhounds in the United States. Although sand flies are widely distributed throughout the United States, epidemiological data do not support a major role for sand flies in the transmission of L. infantum in foxhounds in this country. Congenital transmission of human visceral leishmaniasis is reported in humans and might also occur in dogs. We have previously isolated L. infantum from Virginia foxhounds and used this isolate (LIVT-1) to experimentally infect beagles. Four female beagles, chronically infected with LIVT-I, were bred to a male beagle chronically infected with L. infantum chagasi. One beagle was able to maintain her pregnancy, and 4 puppies were delivered by cesarean section. One puppy was malformed and autolytic at delivery, and tissues were not collected or analyzed. The remaining puppies were killed at the time of cesarean section, and selected tissues were collected for parasite culture and PCR. Promastigotes were not cultured from tissues in any of the puppies. Leishmania sp. DNA was detectable by PCR in liver, bone marrow, and heart from all 3 puppies and in the spleen, lymph node, kidney, and placenta in 2 puppies. Placental tissue from the dam was PCR negative. This is the first report of maternal transmission of a North American isolate of L. infantum from an experimentally infected dog.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAlexa C. Rosypal, Gregory C. Troy, Anne M. Zajac, Glenn Frank, and David S. Lindsay (2005). "Transplacental Transmission of a North American Isolate of Leishmania infantum in an Experimentally Infected Beagle," Journal of Parasitology, Vol. 91, No. 4, pp. 970-972. doi: http://dx.doi.org/10.1645/GE-483R.1en
dc.identifier.doihttps://doi.org/10.1645/ge-483r.1en
dc.identifier.issn0022-3395en
dc.identifier.urihttp://hdl.handle.net/10919/49092en
dc.identifier.urlhttp://www.bioone.org/doi/abs/10.1645/GE-483R.1en
dc.language.isoenen
dc.publisherAmerican Society of Parasitologyen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectcongenital kala-azaren
dc.subjectvisceral leishmaniasisen
dc.subjectcanine leishmaniasisen
dc.subjectsuccessful pregnancyen
dc.subjectnewborn puppyen
dc.subjectunited-statesen
dc.subjectc57bl/6 miceen
dc.subjectifn-gammaen
dc.subjectdogsen
dc.subjectresponsesen
dc.subjectparasitologyen
dc.titleTransplacental transmission of a North American isolate of Leishmania infantum in an experimentally infected beagleen
dc.title.serialJournal of Parasitologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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