COVID-19 Seroprevalence in Canada Modelling Waning and Boosting COVID-19 Immunity in Canada a Canadian Immunization Research Network Study

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dc.contributor.authorDick, David W.en
dc.contributor.authorChilds, Lauren M.en
dc.contributor.authorFeng, Zhilanen
dc.contributor.authorLi, Jingen
dc.contributor.authorRöst, Gergelyen
dc.contributor.authorBuckeridge, David L.en
dc.contributor.authorOgden, Nick H.en
dc.contributor.authorHeffernan, Jane M.en
dc.coverage.countryCanadaen
dc.date.accessioned2022-01-04T13:51:59Zen
dc.date.available2022-01-04T13:51:59Zen
dc.date.issued2021-12-23en
dc.date.updated2021-12-23T15:06:42Zen
dc.description.abstractCOVID-19 seroprevalence changes over time, with infection, vaccination, and waning immunity. Seroprevalence estimates are needed to determine when increased COVID-19 vaccination coverage is needed, and when booster doses should be considered, to reduce the spread and disease severity of COVID-19 infection. We use an age-structured model including infection, vaccination and waning immunity to estimate the distribution of immunity to COVID-19 in the Canadian population. This is the first mathematical model to do so. We estimate that 60–80% of the Canadian population has some immunity to COVID-19 by late Summer 2021, depending on specific characteristics of the vaccine and the waning rate of immunity. Models results indicate that increased vaccination uptake in age groups 12–29, and booster doses in age group 50+ are needed to reduce the severity COVID-19 Fall 2021 resurgence.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDick, D.W.; Childs, L.; Feng, Z.; Li, J.; Röst, G.; Buckeridge, D.L.; Ogden, N.H.; Heffernan, J.M. COVID-19 Seroprevalence in Canada Modelling Waning and Boosting COVID-19 Immunity in Canada a Canadian Immunization Research Network Study. Vaccines 2021, 10, 17.en
dc.identifier.doihttps://doi.org/10.3390/vaccines10010017en
dc.identifier.urihttp://hdl.handle.net/10919/107344en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectseroprevalenceen
dc.subjectCOVID-19en
dc.subjectinfectious disease modellingen
dc.subjectmathematical epidmiologyen
dc.titleCOVID-19 Seroprevalence in Canada Modelling Waning and Boosting COVID-19 Immunity in Canada a Canadian Immunization Research Network Studyen
dc.title.serialVaccinesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
Destination Area: Global Systems Science (GSS)
Scholarly Works, Mathematics