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Ammonium Bisphosphonate Polymeric Magnetic Nanocomplexes for Platinum Anticancer Drug Delivery and Imaging with Potential Hyperthermia and Temperature-Dependent Drug Release

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dc.contributor.authorZhang, Ruien
dc.contributor.authorFellows, Benjaminen
dc.contributor.authorPothayee, Nikornen
dc.contributor.authorHu, Nanen
dc.contributor.authorPothayee, Niponen
dc.contributor.authorJo, Amien
dc.contributor.authorBohórquez, Ana C.en
dc.contributor.authorRinaldi, Carlosen
dc.contributor.authorMefford, Olin Thompsonen
dc.contributor.authorDavis, Richey M.en
dc.contributor.authorRiffle, Judy S.en
dc.contributor.departmentChemical Engineeringen
dc.contributor.departmentChemistryen
dc.contributor.departmentMacromolecules Innovation Instituteen
dc.date.accessioned2018-08-06T13:01:35Zen
dc.date.available2018-08-06T13:01:35Zen
dc.date.issued2018-08-05en
dc.date.updated2018-08-05T07:11:44Zen
dc.description.abstractNovel magnetite-ammonium bisphosphonate graft ionic copolymer nanocomplexes (MGICs) have been developed for potential drug delivery, magnetic resonance imaging, and hyperthermia applications. The complexes displayed relatively uniform sizes with narrow size distributions upon self-assembly in aqueous media, and their sizes were stable under simulated physiological conditions for at least 7 days. The anticancer drugs, cisplatin and carboplatin, were loaded into the complexes, and sustained release of both drugs was observed. The transverse NMR relaxivities (s) of the complexes were 244 s−1 (mM Fe)−1 which is fast compared to either the commercial T2-weighted MRI agent Feridex IV® or our previously reported magnetite-block ionomer complexes. Phantom MRI images of the complexes demonstrated excellent negative contrast effects of such complexes. Thus, the bisphosphonate-bearing MGICs could be promising candidates for dual drug delivery and magnetic resonance imaging. Moreover, the bisphosphonate MGICs generate heat under an alternating magnetic field of 30 kA·m−1 at 206 kHz. The temperature of the MGIC dispersion in deionized water increased from 37 to 41°C after exposure to the magnetic field for 10 minutes, corresponding to a specific absorption rate of 77.0 W·g−1. This suggests their potential as hyperthermia treatment agents as well as the possibility of temperature-dependent drug release, making MGICs more versatile in potential drug delivery applications.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRui Zhang, Benjamin Fellows, Nikorn Pothayee, et al., “Ammonium Bisphosphonate Polymeric Magnetic Nanocomplexes for Platinum Anticancer Drug Delivery and Imaging with Potential Hyperthermia and Temperature-Dependent Drug Release,” Journal of Nanomaterials, vol. 2018, Article ID 4341580, 14 pages, 2018. doi:10.1155/2018/4341580en
dc.identifier.doihttps://doi.org/10.1155/2018/4341580en
dc.identifier.urihttp://hdl.handle.net/10919/84506en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2018 Rui Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleAmmonium Bisphosphonate Polymeric Magnetic Nanocomplexes for Platinum Anticancer Drug Delivery and Imaging with Potential Hyperthermia and Temperature-Dependent Drug Releaseen
dc.title.serialJournal of Nanomaterialsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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