A Human Serum-Based Enzyme-Free Continuous Glucose Monitoring Technique Using a Needle-Type Bio-Layer Interference Sensor

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dc.contributor.authorSeo, Dongminen
dc.contributor.authorPaek, Sung-Hoen
dc.contributor.authorOh, Sangwooen
dc.contributor.authorSeo, Sungkyuen
dc.contributor.authorPaek, Se-Hwanen
dc.contributor.departmentBiological Systems Engineeringen
dc.date.accessioned2017-09-20T18:27:38Zen
dc.date.available2017-09-20T18:27:38Zen
dc.date.issued2016-09-24en
dc.date.updated2017-09-20T18:27:38Zen
dc.description.abstractThe incidence of diabetes is continually increasing, and by 2030, it is expected to have increased by 69% and 20% in underdeveloped and developed countries, respectively. Therefore, glucose sensors are likely to remain in high demand in medical device markets. For the current study, we developed a needle-type bio-layer interference (BLI) sensor that can continuously monitor glucose levels. Using dialysis procedures, we were able to obtain hypoglycemic samples from commercial human serum. These dialysis-derived samples, alongside samples of normal human serum were used to evaluate the utility of the sensor for the detection of the clinical interest range of glucose concentrations (70–200 mg/dL), revealing high system performance for a wide glycemic state range (45–500 mg/dL). Reversibility and reproducibility were also tested over a range of time spans. Combined with existing BLI system technology, this sensor holds great promise for use as a wearable online continuous glucose monitoring system for patients in a hospital setting.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSeo, D.; Paek, S.-H.; Oh, S.; Seo, S.; Paek, S.-H. A Human Serum-Based Enzyme-Free Continuous Glucose Monitoring Technique Using a Needle-Type Bio-Layer Interference Sensor. Sensors 2016, 16, 1581.en
dc.identifier.doihttps://doi.org/10.3390/s16101581en
dc.identifier.urihttp://hdl.handle.net/10919/79293en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectcontinuous glucose monitoringen
dc.subjectcompetitive assayen
dc.subjectglucose dialysis methoden
dc.subjectbio-layer interferometryen
dc.subjectneedle-type sensoren
dc.titleA Human Serum-Based Enzyme-Free Continuous Glucose Monitoring Technique Using a Needle-Type Bio-Layer Interference Sensoren
dc.title.serialSensorsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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