Diagnostic accuracy of stereotactic brain biopsy for intracranial neoplasia in dogs: Comparison of biopsy, surgical resection, and necropsy specimens

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dc.contributor.authorKani, Yukitakaen
dc.contributor.authorCecere, Thomas E.en
dc.contributor.authorLahmers, Kevin K.en
dc.contributor.authorLeRoith, Tanyaen
dc.contributor.authorZimmerman, Kurt L.en
dc.contributor.authorIsom, Scotten
dc.contributor.authorHsu, Fang-Chien
dc.contributor.authorDebinski, Waldemaren
dc.contributor.authorRobertson, John L.en
dc.contributor.authorRossmeisl, John H. Jr.en
dc.date.accessioned2019-08-05T17:19:28Zen
dc.date.available2019-08-05T17:19:28Zen
dc.date.issued2019-05en
dc.description.abstractBackground Stereotactic brain biopsy (SBB) is a technique that allows for definitive diagnosis of brain lesions. Little information is available regarding the diagnostic utility of SBB in dogs with intracranial diseases. Objective To investigate the diagnostic accuracy (DA) of SBB in dogs with brain tumors. Animals Thirty-one client-owned dogs that underwent SBB followed by surgical resection or necropsy examinations. Methods Retrospective observational study. Two pathologists blinded to SBB and reference standard diagnoses reviewed histologic specimens and typed and graded tumors according to World Health Organization and revised canine glioma classification criteria. Agreement between tumor type and grade from SBB were compared to reference standards and assessed using kappa statistics. Patient and technical factors associated with agreement also were examined. Results Stereotactic brain biopsy specimens were obtained from 24 dogs with gliomas and 7 with meningiomas. Tumor type agreement between SBB and the reference standard was observed in 30/31 cases (kappa = 0.95). Diagnostic concordance was perfect for meningiomas. Grade agreement among gliomas was observed in 18/23 cases (kappa = 0.47). Stereotactic brain biopsy underrepresented the reference standard glioma grade in cases with disagreement. The DA of SBB was 81%, with agreement noted in 56/69 biopsy samples. Smaller tumors and fewer SBB specimens obtained were significantly associated with diagnostic discordance. Conclusions and Clinical Importance The DA of SBB readily allows for the diagnosis of common brain tumors in dogs. Although glioma grade discordance was frequent, diagnoses obtained from SBB are sufficient to currently inform therapeutic decisions. Multiple SBB specimens should be collected to maximize DA.en
dc.description.notesNational Institutes of Health/National Cancer Institute, Grant/Award Number: P01CA207206 and R01CA213423en
dc.description.sponsorshipNational Institutes of Health/National Cancer Institute [P01CA207206, R01CA213423]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/jvim.15500en
dc.identifier.eissn1939-1676en
dc.identifier.issn0891-6640en
dc.identifier.issue3en
dc.identifier.pmid30990928en
dc.identifier.urihttp://hdl.handle.net/10919/92742en
dc.identifier.volume33en
dc.language.isoenen
dc.publisherAmerican College of Veterinary Internal Medicineen
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectbiopsyen
dc.subjectbrain tumoren
dc.subjectdiagnosisen
dc.subjectdogen
dc.subjectgliomaen
dc.subjectmeningiomaen
dc.titleDiagnostic accuracy of stereotactic brain biopsy for intracranial neoplasia in dogs: Comparison of biopsy, surgical resection, and necropsy specimensen
dc.title.serialJournal of Veterinary Internal Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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