Computational models in plant-pathogen interactions: the case of Phytophthora infestans

Pinzón, Andrés; Barreto, Emiliano; Bernal, Adriana; Achenie, Luke E. K.; González Barrios, Andrés Fernando; Isea, Raúl; Restrepo, Silvia

Computational models in plant-pathogen interactions: the case of Phytophthora infestans

dc.contributor.author	Pinzón, Andrés	en
dc.contributor.author	Barreto, Emiliano	en
dc.contributor.author	Bernal, Adriana	en
dc.contributor.author	Achenie, Luke E. K.	en
dc.contributor.author	González Barrios, Andrés Fernando	en
dc.contributor.author	Isea, Raúl	en
dc.contributor.author	Restrepo, Silvia	en
dc.contributor.department	Chemical Engineering	en
dc.date.accessioned	2012-08-24T11:58:26Z	en
dc.date.available	2012-08-24T11:58:26Z	en
dc.date.issued	2009-11-12	en
dc.date.updated	2012-08-24T11:58:26Z	en
dc.description.abstract	Background Phytophthora infestans is a devastating oomycete pathogen of potato production worldwide. This review explores the use of computational models for studying the molecular interactions between P. infestans and one of its hosts, Solanum tuberosum. Modeling and conclusion Deterministic logistics models have been widely used to study pathogenicity mechanisms since the early 1950s, and have focused on processes at higher biological resolution levels. In recent years, owing to the availability of high throughput biological data and computational resources, interest in stochastic modeling of plant-pathogen interactions has grown. Stochastic models better reflect the behavior of biological systems. Most modern approaches to plant pathology modeling require molecular kinetics information. Unfortunately, this information is not available for many plant pathogens, including P. infestans. Boolean formalism has compensated for the lack of kinetics; this is especially the case where comparative genomics, protein-protein interactions and differential gene expression are the most common data resources.	en
dc.description.version	Published version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Theoretical Biology and Medical Modelling. 2009 Nov 12;6(1):24	en
dc.identifier.doi	https://doi.org/10.1186/1742-4682-6-24	en
dc.identifier.uri	http://hdl.handle.net/10919/18891	en
dc.language.iso	en	en
dc.rights	Creative Commons Attribution 4.0 International	en
dc.rights.holder	Andrés Pinzón et al.; licensee BioMed Central Ltd.	en
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	en
dc.title	Computational models in plant-pathogen interactions: the case of Phytophthora infestans	en
dc.title.serial	Theoretical Biology and Medical Modelling	en
dc.type	Article - Refereed	en
dc.type.dcmitype	Text	en