Impact of surface topography on biofilm formation by Candida albicans

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dc.contributor.authorLagree, Katherineen
dc.contributor.authorMon, Htwe H.en
dc.contributor.authorMitchell, Aaron P.en
dc.contributor.authorDucker, William A.en
dc.contributor.departmentChemical Engineeringen
dc.date.accessioned2018-07-24T17:01:38Zen
dc.date.available2018-07-24T17:01:38Zen
dc.date.issued2018-06-18en
dc.description.abstractCandida albicans is a fungal pathogen that causes serious biofilm-based infections. Here we have asked whether surface topography may affect C. albicans biofilm formation. We tested biofilm growth of the prototypical wild-type strain SC5314 on a series of polydimethylsiloxane (PDMS) solids. The surfaces were prepared with monolayer coatings of monodisperse spherical silica particles that were fused together into a film using silica menisci. The surface topography was varied by varying the diameter of the silica particles that were used to form the film. Biofilm formation was observed to be a strong function of particle size. In the particle size range 4.0±8.0 μm, there was much more biofilm than in the size range 0.5± 2.0 μm. The behavior of a clinical isolate from a clade separate from SC5314, strain p76067, showed results similar to that of SC5314. Our results suggest that topographic coatings may be a promising approach to reduce C. albicans biofilm infections.en
dc.description.sponsorshipVirginia Commonwealth Commercialization Fund (CRCF)en
dc.description.sponsorshipCRCF: MF15-010-LS (WAD)en
dc.description.sponsorshipNIH/NIAID: 1R21AI135178 (APM)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0197925en
dc.identifier.issue6en
dc.identifier.urihttp://hdl.handle.net/10919/84322en
dc.identifier.volume13en
dc.language.isoen_USen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleImpact of surface topography on biofilm formation by Candida albicansen
dc.title.serialPLOS ONEen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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