Structure-property-processing relationships between polymeric solutions and additive manufacturing for biomedical applications
| dc.contributor.author | Wilts, Emily Marie | en |
| dc.contributor.committeechair | Long, Timothy E. | en |
| dc.contributor.committeemember | Moore, Robert Bowen | en |
| dc.contributor.committeemember | Bortner, Michael J. | en |
| dc.contributor.committeemember | Williams, Christopher Bryant | en |
| dc.contributor.committeemember | Schulz, Michael | en |
| dc.contributor.department | Chemistry | en |
| dc.date.accessioned | 2022-03-26T06:00:07Z | en |
| dc.date.available | 2022-03-26T06:00:07Z | en |
| dc.date.issued | 2020-10-01 | en |
| dc.description.abstract | Additive manufacturing (AM) creates 3D objects out of polymers, ceramics, and metals to enable cost-efficient and rapid production of products from aerospace to biomedical applications. Personalized products manufactured using AM, such as personalized dosage pharmaceuticals, tissue scaffolds, and medical devices, require specific material properties such as biocompatibility and biodegradability, etc. Polymers possess many of these qualities and tuning molecular structure enables a functional material to successfully deliver the intended application. For example, water-soluble polymers such as poly(vinyl pyrrolidone) and poly(ethylene glycol) both function as drug delivery materials because of their inherit water-solubility and biocompatibility. Other polymers such as polylactide and polyglycolide possess hydrolytically cleavable functionalities, which enables degradation in the body. Non-covalent bonds, such as hydrogen bonding and electrostatic interactions, enable strong connections capable of holding materials together, but disconnect with heat or solvation. Taking into consideration some of these polymer functionalities, this dissertation investigates how to utilize them to create functional biomedical products using AM. The investigation of structure-property-processing relationships of polymer molecular structures, physical properties, and processing behaviors is transforming the field of new materials for AM. Even though novel, functional materials for AM continue to be developed, requirements that render a polymeric material printable remain unknown or vague for most AM processes. Materials and printers are usually developed separately, which creates a disconnect between the material printing requirements and fundamental physical properties that enable successful printing. Through the interface of chemistry, biology, chemical engineering, and mechanical engineering, this dissertation aims to relate printability of polymeric materials with three types of AM processes, namely vat photopolymerization, binder jetting, and powder bed fusion. Binder jetting, vat photopolymerization, and powder bed fusion require different viscosity and powder requirements depending on the printer capabilities, and if the material is neat or in solution. Developing scaling relationships between solution viscosity and concentration determined critical overlap (C*) and entanglement (Ce) concentrations, which are related to the printability of the materials. For example, this dissertation discusses and investigates the maximum printable concentration in binder jetting of multiple polymer architectures in solution as a function of C* values of the polymer. For thermal-type printheads, C* appeared to be the highest jettable concentration, which asserted an additional method of material screening for binder jetting. Another investigation of the photokinetics as a function of concentration of photo-active polymers in solution revealed increased viscosity leads to decreased acrylate/acrylamide conversion. Lastly, investigating particle size and shape of poly(stearyl acrylate) particles synthesized through suspension polymerization revealed a combination of crosslinked and linear polymers produced high resolution parts for phase change materials. These analytical screening methods will help the progression of AM and provide future scientists and engineers a better guideline for material screenings. | en |
| dc.description.abstractgeneral | Additive manufacturing (AM), also known as 3D printing, enables the creation of 3D objects in a rapid and cost-efficient manner for applications from aerospace to biomedical sectors. AM particularly benefits the field of personalized biomedical products, such as personalized dosage pharmaceuticals, hearing aids, and prosthetic limbs. In the future, advanced detection and prevention medical screenings will provide doctors, pharmacists, and engineers very precise data to enable personalized healthcare. For example, a patient can take three different medications in one pill with the exact dosage to prevent side-effects and drug-drug interactions. AM enables the delivery and manufacturing of these personalized systems and will improve healthcare in every sector. Investigations of the most effective materials is needed for personalized medicine to become a reality. Polymers, or macromolecules, provide a highly tunable material to become printable with slight chemical modifications. Investigation of how chemical structure affects properties, such as strength, stretchability, or viscosity, will dictate how they perform in a manufacturing setting. This process of investigation is called "structure-property-processing" relationships, which connects scientists and engineers through all disciplines. This method is used to discover which polymers will not only 3D print, but also carry medication to a patient or deliver therapeutics within the body. | en |
| dc.description.degree | Doctor of Philosophy | en |
| dc.format.medium | ETD | en |
| dc.identifier.other | vt_gsexam:27539 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/109442 | en |
| dc.publisher | Virginia Tech | en |
| dc.rights | In Copyright | en |
| dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | en |
| dc.subject | additive manufacturing | en |
| dc.subject | binder jetting | en |
| dc.subject | vat photopolymerization | en |
| dc.subject | RAFT polymerization | en |
| dc.subject | poly(vinyl pyrrolidone) | en |
| dc.subject | ring-opening polymerization | en |
| dc.subject | photo-kinetics | en |
| dc.title | Structure-property-processing relationships between polymeric solutions and additive manufacturing for biomedical applications | en |
| dc.type | Dissertation | en |
| thesis.degree.discipline | Macromolecular Science and Engineering | en |
| thesis.degree.grantor | Virginia Polytechnic Institute and State University | en |
| thesis.degree.level | doctoral | en |
| thesis.degree.name | Doctor of Philosophy | en |