Registration of Images with Varying Topology using Embedded Maps

dc.contributor.authorLi, Xiaoxingen
dc.contributor.committeechairWyatt, Christopher L.en
dc.contributor.committeememberBaumann, William T.en
dc.contributor.committeememberBeex, A. A. Louisen
dc.contributor.committeememberWang, Geen
dc.contributor.committeememberXuan, Jianhua Jasonen
dc.contributor.departmentElectrical and Computer Engineeringen
dc.date.accessioned2014-03-14T20:18:48Zen
dc.date.adate2010-12-01en
dc.date.available2014-03-14T20:18:48Zen
dc.date.issued2010-11-16en
dc.date.rdate2010-12-01en
dc.date.sdate2010-11-19en
dc.description.abstractIn medical images, intensity changes caused by certain pathology can change the topology of image level-sets and are thus commonly referred to as topological changes. Topological changes cause false deformation in existing deformable registration algorithms, which in turn leads to unreliable observations in the clinical study that relies on the deformation fields, such as deformation based morphometry (DBM). In this work, we develop a new deformable registration algorithm for images with topological changes. In our proposed algorithm, 3D images are embedded as 4D surfaces in a Riemannian space. The registration is therefore conducted as a surface evolution, which is modeled by a diffusion process. Our algorithm differs from existing methods in the sense that it takes an a-priori estimation of areas with topological change as an additional input and generates dense deformation vector fields which are free of false deformation. In particular, the output of our algorithm is composed of a diffeomorphic deformation field and an intensity displacement which corrects intensity difference caused by topological changes. By conducting multiple sets of experiments, we demonstrate that our proposed algorithm is capable of accurately registering images with considerable topological changes. More importantly, the resulting deformation field is not impacted by topological changes, i.e., there is no false deformation.en
dc.description.degreePh. D.en
dc.identifier.otheretd-11192010-120208en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-11192010-120208/en
dc.identifier.urihttp://hdl.handle.net/10919/29683en
dc.publisherVirginia Techen
dc.relation.haspartLi_X_D_2010.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectregistrationen
dc.subjectdeformableen
dc.subjectRiemannian embeddingen
dc.subjecttopological changeen
dc.titleRegistration of Images with Varying Topology using Embedded Mapsen
dc.typeDissertationen
thesis.degree.disciplineElectrical and Computer Engineeringen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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