Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof

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dc.contributor.assigneeVirginia Tech Intellectual Properties, Inc.en
dc.contributor.assigneeIowa State University Reserach Foundation, Inc.en
dc.contributor.inventorMeng, Xiang-Jinen
dc.contributor.inventorHalbur, Patrick G.en
dc.contributor.inventorFenaux, Martijnen
dc.date.accessed2019-02-15en
dc.date.accessioned2019-02-26T22:24:00Zen
dc.date.available2019-02-26T22:24:00Zen
dc.date.filed2015-11-13en
dc.date.issued2018-02-13en
dc.description.abstractThe present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.en
dc.format.mimetypeapplication/pdfen
dc.identifier.applicationnumber14940799en
dc.identifier.patentnumber9889187en
dc.identifier.urihttp://hdl.handle.net/10919/87832en
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/87/891/098/0.pdfen
dc.language.isoenen
dc.publisherUnited States Patent and Trademark Officeen
dc.subject.cpcA61K39/12en
dc.subject.cpcA61K2039/5252en
dc.subject.cpcA61K2039/5254en
dc.subject.cpcA61K2039/5256en
dc.subject.cpcA61K2039/53en
dc.subject.cpcA61K2039/54en
dc.subject.cpcA61K2039/552en
dc.subject.cpcC07K14/005en
dc.subject.cpcC12N7/00en
dc.subject.cpcC12N2750/10022en
dc.subject.cpcC12N2750/10034en
dc.subject.cpcC12N2750/10061en
dc.titleChimeric infectious DNA clones, chimeric porcine circoviruses and uses thereofen
dc.typePatenten
dc.type.dcmitypeTexten
dc.type.patenttypeutilityen

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