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Oxytocin-induced cervical dilation in sheep: mechanism of action and potential use for nonsurgical artificial insemination

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dc.contributor.authorSayre, Brian L.en
dc.contributor.committeechairLewis, Gregory S.S.en
dc.contributor.committeememberKnight, James W.en
dc.contributor.committeememberSaacke, Richard G.en
dc.contributor.committeememberAkers, Robert Michaelen
dc.contributor.committeememberUmberger, Steven H.en
dc.contributor.departmentAnimal Science (Physiology of Reproduction)en
dc.date.accessioned2014-03-14T21:22:35Zen
dc.date.adate2005-10-26en
dc.date.available2014-03-14T21:22:35Zen
dc.date.issued1995en
dc.date.rdate2005-10-26en
dc.date.sdate2005-10-26en
dc.description.abstractExogenous oxytocin aids in the transcervical passage of an AI pipette into the uterus of ewes, and it may be an effective adjunct to sheep AI procedures. Experiments were conducted to evaluate the effects of oxytocin on variables that may affect fertility. The results of this study indicate clearly that oxytocin dilates the cervix in ewes (Exp. 1) without affecting the movement of sperm to the oviducts (Exp. 3) or fertilization rate (Exp. 9). Oxytocin probably binds to uterine and cervical receptors (Exp. 6) and stimulates uterine tetany (Exp. 2) and prostaglandin release (Exp. 5). Because of the irregular arrangement of smooth muscle in the sheep cervix (Exp. 4), uterine tetany may physically dilate the cervix. Also, prostaglandin synthesis, primarily PGF2, may be involved in a chemical softening of the cervix. Most likely, a combination of uterine contractions and cervical softening allow dilation and transcervical passage of an AI pipette. Although oxytocin does not affect sperm transport (Exp. 3) or fertilization (Exp. 9), fertility after transcervical AI is decreased (Exp. 8). Cervical manipulation seems to decrease fertility, but the mechanism is unclear. Therefore, a greater understanding of the physiology of the sheep cervix is necessary before oxytocin-induced cervical dilation can be implemented with nonsurgical AI procedures in sheep.en
dc.description.degreePh. D.en
dc.format.extentvii, 103 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-10262005-143554en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-10262005-143554/en
dc.identifier.urihttp://hdl.handle.net/10919/40251en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V856_1995.S397.pdfen
dc.relation.isformatofOCLC# 51507228en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V856 1995.S397en
dc.subject.lcshOxytocin -- Researchen
dc.subject.lcshSheep -- Artificial inseminationen
dc.titleOxytocin-induced cervical dilation in sheep: mechanism of action and potential use for nonsurgical artificial inseminationen
dc.typeDissertationen
dc.type.dcmitypeTexten
thesis.degree.disciplineAnimal Science (Physiology of Reproduction)en
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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