Algebraic Methods for Modeling Gene Regulatory Networks

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dc.contributor.authorMurrugarra Tomairo, David M.en
dc.contributor.committeechairLaubenbacher, Reinhard C.en
dc.contributor.committeememberMortveit, Henning S.en
dc.contributor.committeememberCiupe, Stanca M.en
dc.contributor.committeememberHoops, Stefanen
dc.contributor.departmentMathematicsen
dc.date.accessioned2014-03-14T20:14:16Zen
dc.date.adate2012-08-01en
dc.date.available2014-03-14T20:14:16Zen
dc.date.issued2012-07-18en
dc.date.rdate2012-08-01en
dc.date.sdate2012-07-24en
dc.description.abstractSo called discrete models have been successfully used in engineering and computational systems biology. This thesis discusses algebraic methods for modeling and analysis of gene regulatory networks within the discrete modeling context. The first chapter gives a background for discrete models and put in context some of the main research problems that have been pursued in this field for the last fifty years. It also outlines the content of each subsequent chapter. The second chapter focuses on the problem of inferring dynamics from the structure (topology) of the network. It also discusses the characterization of the attractor structure of a network when a particular class of functions control the nodes of the network. Chapters~3 and 4 focus on the study of multi-state nested canalyzing functions as biologically inspired functions and the characterization of their dynamics. Chapter 5 focuses on stochastic methods, specifically on the development of a stochastic modeling framework for discrete models. Stochastic discrete modeling is an alternative approach from the well-known mathematical formalizations such as stochastic differential equations and Gillespie algorithm simulations. Within the discrete setting, a framework that incorporates propensity probabilities for activation and degradation is presented. This approach allows a finer analysis of discrete models and provides a natural setup for cell population simulations. Finally, Chapter 6 discusses future research directions inspired by the work presented here.en
dc.description.degreePh. D.en
dc.identifier.otheretd-07242012-153925en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-07242012-153925/en
dc.identifier.urihttp://hdl.handle.net/10919/28388en
dc.publisherVirginia Techen
dc.relation.haspartMurrugarra_D_D_2012.pdfen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectSystems Biologyen
dc.subjectStochastic Discrete Modelingen
dc.subjectIntrinsic Noise.en
dc.subjectNested Canalyzing Functionsen
dc.subjectGene Regulatory Networksen
dc.subjectRobustnessen
dc.titleAlgebraic Methods for Modeling Gene Regulatory Networksen
dc.typeDissertationen
thesis.degree.disciplineMathematicsen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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