Host Lipids in Positive-Strand RNA Virus Genome Replication

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dc.contributor.authorZhang, Zhenluen
dc.contributor.authorHe, Guijuanen
dc.contributor.authorFilipowicz, Natalie A.en
dc.contributor.authorRandall, Glennen
dc.contributor.authorBelov, George A.en
dc.contributor.authorKopek, Benjamin G.en
dc.contributor.authorWang, Xiaofengen
dc.contributor.departmentSchool of Plant and Environmental Sciencesen
dc.date.accessioned2019-03-13T18:34:26Zen
dc.date.available2019-03-13T18:34:26Zen
dc.date.issued2019-02-26en
dc.description.abstractMembrane association is a hallmark of the genome replication of positive-strand RNA viruses [(+)RNA viruses]. All well-studied (+)RNA viruses remodel host membranes and lipid metabolism through orchestrated virus-host interactions to create a suitable microenvironment to survive and thrive in host cells. Recent research has shown that host lipids, as major components of cellular membranes, play key roles in the replication of multiple (+)RNA viruses. This review focuses on how (+)RNA viruses manipulate host lipid synthesis and metabolism to facilitate their genomic RNA replication, and how interference with the cellular lipid metabolism affects viral replication.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fmicb.2019.00286en
dc.identifier.issn1664-302Xen
dc.identifier.other286en
dc.identifier.urihttp://hdl.handle.net/10919/88432en
dc.identifier.volume10en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleHost Lipids in Positive-Strand RNA Virus Genome Replicationen
dc.title.serialFrontiers in Microbiologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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