The effect of different sources of dietary fiber on the plasma total and lipoprotein cholesterol, liver cholesterol, fecal neutral steroid excretion and histology of major organ tissues in hamsters

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dc.contributor.authorJonnalagadda, Satya Srivathsaen
dc.contributor.committeechairThye, Forrest W.en
dc.contributor.committeememberPolan, Carl E.en
dc.contributor.committeememberRitchey, Sanford J.en
dc.contributor.committeememberSchlenker, Eleanor D.en
dc.contributor.committeememberTaper, L. Janetteen
dc.contributor.departmentHuman Nutrition and Foodsen
dc.date.accessioned2014-03-14T21:20:42Zen
dc.date.adate2005-10-10en
dc.date.available2014-03-14T21:20:42Zen
dc.date.issued1992-05-05en
dc.date.rdate2005-10-10en
dc.date.sdate2005-10-10en
dc.description.abstractThe effect of diets with various dietary fiber sources on the plasma lipids, liver cholesterol, the histology of the gastrointestinal tract, heart, liver and kidney and the fecal neutral steroid excretion was investigated in hamsters. 155, 9-11 wk old, male Golden-syrian hamsters were fed a purified basal hypercholesterolemic diet (0.1% cholesterol, 10% fat, 4% dietary fiber) for 5 wk to elevate plasma lipid levels. Based on wk 4 plasma total cholesterol (TC) levels hamsters with elevated levels were randomly assigned, 16 animals/group, into six groups for another 4 wk: control, oat bran, guar gum, cellulose, xylan and sacrifice. After 4 wk of the fiber diets (10% dietary fiber), the plasma TC levels were significantly lowered in the oat bran, guar gum and xylan groups (16%, 12% and 15%, respectively) (p<.05). They were also significantly lower than the control and cellulose groups. Plasma HDL-C concentrations tended to be lower in all the treatment groups, but was significantly decreased only in the guar gum group (12%) (p<.05). The combined plasma VLDL-C + LDL-C was significantly lowered by the oat bran, cellulose and xylan diets (38%, 40% and 34%, respectively) (p<.05). The liver cholesterol concentration increased significantly from 1 mg cholesterol/g liver to 4.1 mg cholesterol/g liver (p<.05) after 4 wk of the control diet; this was further increased significantly only in the cellulose group (5.6 mg cholesterol/g liver), while the other treatment groups showed no significant changes or differences compared to the control diet group (wk 4). The total fecal neutral steroid excretion was significantly (p<.05) higher in the oat bran group compared to the other treatment groups. No major differences were observed in the tissue histology of the animals in the different treatment groups. In the present study, it appeared that oat bran, guar gum and xylan were effective hypocholesterolemic agents; however, their mechanism of action is still not clear.en
dc.description.degreePh. D.en
dc.format.extentxi, 180 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-10102005-131551en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-10102005-131551/en
dc.identifier.urihttp://hdl.handle.net/10919/39709en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V856_1992.J666.pdfen
dc.relation.isformatofOCLC# 26336280en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V856 1992.J666en
dc.subject.lcshAnticholesteremic agentsen
dc.subject.lcshCholesterolen
dc.subject.lcshFiber in human nutritionen
dc.subject.lcshHamsters -- Physiologyen
dc.subject.lcshLipoproteinsen
dc.titleThe effect of different sources of dietary fiber on the plasma total and lipoprotein cholesterol, liver cholesterol, fecal neutral steroid excretion and histology of major organ tissues in hamstersen
dc.typeDissertationen
dc.type.dcmitypeTexten
thesis.degree.disciplineHuman Nutrition and Foodsen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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