Comparative Genomics Insights into Speciation and Evolution of Hawaiian Drosophila

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dc.contributor.authorKang, Linen
dc.contributor.committeechairSharakhov, Igor V.en
dc.contributor.committeememberXie, Hehuang Daviden
dc.contributor.committeememberZhang, Liqingen
dc.contributor.committeememberMichalak, Pawelen
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2018-10-24T06:00:38Zen
dc.date.available2018-10-24T06:00:38Zen
dc.date.issued2017-05-01en
dc.description.abstractSpeciation and adaptation have always been of great interest to biologists. The Hawaiian archipelago provides a natural arena for understanding adaptive radiation and speciation, and genomics and bioinformatics offer new approaches for studying these fundamental processes. The mode of speciation should have profound impacts on the genomic architecture and patterns of reproductive isolation of new species. The Hawaiian Drosophila are a spectacular example of sequential colonization, adaptive radiation, and speciation in the islands with nearly 1,000 estimated species, of which more than 500 have been described to date. This dissertation gives an overview of the Hawaiian Drosophila system (Chapter 1), new insights into genomes of three recently diverged species of Hawaiian picture-winged Drosophila (Chapter 2), as well as estimated gene flow patterns (Chapter 3). Additionally, I present a new approach of mapping genomic scaffolds onto chromosomes, based on NextGen sequencing from chromosomal microdissections (Chapter 4), and gene expression profiles of backcross hybrids and their parental forms (Chapter 5). Overall, obtained results were used to address such fundamental questions as the role of adaptive changes, founder effects (small effective population size in isolation), and genetic admixture during speciation.en
dc.description.degreePh. D.en
dc.format.mediumETDen
dc.identifier.othervt_gsexam:10219en
dc.identifier.urihttp://hdl.handle.net/10919/85467en
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectGenomicsen
dc.subjectComparative genomicsen
dc.subjectDrosophilaen
dc.subjectEvolutionen
dc.subjectAdaptationen
dc.titleComparative Genomics Insights into Speciation and Evolution of Hawaiian Drosophilaen
dc.typeDissertationen
thesis.degree.disciplineGenetics, Bioinformatics, and Computational Biologyen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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