Crosstalk between the Circadian Clock and Innate Immunity in Arabidopsis

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dc.contributor.authorZhang, Chongen
dc.contributor.authorXie, Qiguangen
dc.contributor.authorAnderson, Ryan G.en
dc.contributor.authorNg, Ginaen
dc.contributor.authorSeitz, Nicholas C.en
dc.contributor.authorPeterson, Thomasen
dc.contributor.authorMcClung, C. Robertsonen
dc.contributor.authorMcDowell, John M.en
dc.contributor.authorKong, Dongdongen
dc.contributor.authorKwak, June M.en
dc.contributor.authorLu, Huaen
dc.contributor.departmentSchool of Plant and Environmental Sciencesen
dc.date.accessioned2018-12-04T18:42:15Zen
dc.date.available2018-12-04T18:42:15Zen
dc.date.issued2013-06-06en
dc.description.abstractThe circadian clock integrates temporal information with environmental cues in regulating plant development and physiology. Recently, the circadian clock has been shown to affect plant responses to biotic cues. To further examine this role of the circadian clock, we tested disease resistance in mutants disrupted in CCA1 and LHY, which act synergistically to regulate clock activity. We found that cca1 and lhy mutants also synergistically affect basal and resistance gene-mediated defense against Pseudomonas syringae and Hyaloperonospora arabidopsidis. Disrupting the circadian clock caused by overexpression of CCA1 or LHY also resulted in severe susceptibility to P. syringae. We identified a downstream target of CCA1 and LHY, GRP7, a key constituent of a slave oscillator regulated by the circadian clock and previously shown to influence plant defense and stomatal activity. We show that the defense role of CCA1 and LHY against P. syringae is at least partially through circadian control of stomatal aperture but is independent of defense mediated by salicylic acid. Furthermore, we found defense activation by P. syringae infection and treatment with the elicitor flg22 can feedback-regulate clock activity. Together this data strongly supports a direct role of the circadian clock in defense control and reveal for the first time crosstalk between the circadian clock and plant innate immunity.en
dc.description.sponsorshipThis work was supported by a grant from National Science Foundation (RIG-0818651) to HL, grants from the National Science Foundation (IOS-0605736 and IOS-1025965) to CRM, and a scholarship from China Scholarship Council to CZ. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.format.extent14 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.ppat.1003370en
dc.identifier.eissn1553-7374en
dc.identifier.issn1553-7366en
dc.identifier.issue6en
dc.identifier.othere1003370en
dc.identifier.pmid23754942en
dc.identifier.urihttp://hdl.handle.net/10919/86222en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectsystemic acquired-resistanceen
dc.subjectrna-binding proteinen
dc.subjectpattern-recognition receptorsen
dc.subjectpseudo-response regulatorsen
dc.subjecttranscription factoren
dc.subjectmediated defenseen
dc.subjectphotoperiodic controlen
dc.subjectethylene productionen
dc.subjectbacterial invasionen
dc.subjectdisease resistanceen
dc.titleCrosstalk between the Circadian Clock and Innate Immunity in Arabidopsisen
dc.title.serialPLOS Pathogensen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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