Review of MEMS differential scanning calorimetry for biomolecular study

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dc.contributor.authorYu, Shifengen
dc.contributor.authorWang, Shuyuen
dc.contributor.authorLu, Mingen
dc.contributor.authorZuo, Leien
dc.contributor.departmentMechanical Engineeringen
dc.date.accessioned2019-09-17T19:20:05Zen
dc.date.available2019-09-17T19:20:05Zen
dc.date.issued2017-12en
dc.description.abstractDifferential scanning calorimetry (DSC) is one of the few techniques that allow direct determination of enthalpy values for binding reactions and conformational transitions in biomolecules. It provides the thermodynamics information of the biomolecules which consists of Gibbs free energy, enthalpy and entropy in a straightforward manner that enables deep understanding of the structure function relationship in biomolecules such as the folding/unfolding of protein and DNA, and ligand bindings. This review provides an up to date overview of the applications of DSC in biomolecular study such as the bovine serum albumin denaturation study, the relationship between the melting point of lysozyme and the scanning rate. We also introduce the recent advances of the development of micro-electro-mechanic-system (MEMS) based DSCs.en
dc.description.notesThe authors thank the funding support from NSF (IDBR #1530508) and Abbvie Inc. The authors also thank Dr. Fernando Camino for the discussion.en
dc.description.sponsorshipNSF (IDBR) [1530508]; Abbvie Inc.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1007/s11465-017-0451-0en
dc.identifier.eissn2095-0241en
dc.identifier.issn2095-0233en
dc.identifier.issue4en
dc.identifier.urihttp://hdl.handle.net/10919/93742en
dc.identifier.volume12en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectdifferential scanning calorimetryen
dc.subjectbiomoleculeen
dc.subjectMEMSen
dc.subjectthermodynamicen
dc.titleReview of MEMS differential scanning calorimetry for biomolecular studyen
dc.title.serialFrontiers of Mechanical Engineeringen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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