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Potentially zoonotic gastrointestinal nematodes co-infecting free ranging non-human primates in Kenyan urban centres

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dc.contributor.authorMbuthia, Perisen
dc.contributor.authorMurungi, Edwinen
dc.contributor.authorOwino, Vincenten
dc.contributor.authorAkinyi, Mercyen
dc.contributor.authorEastwood, Gillianen
dc.contributor.authorNyamota, Richarden
dc.contributor.authorLekolool, Isaacen
dc.contributor.authorJeneby, Maamunen
dc.contributor.departmentEntomologyen
dc.date.accessioned2021-06-07T18:37:05Zen
dc.date.available2021-06-07T18:37:05Zen
dc.date.issued2021-01en
dc.description.abstractBackground: Natural infections with soil-transmitted nematodes occur in non-human primates (NHPs) and have the potential to cross primate-species boundaries and cause diseases of significant public health concern. Despite the presence of NHPs in most urban centres in Kenya, comprehensive studies on their gastrointestinal parasites are scant. Objective: Conduct a cross-sectional survey to identify zoonotic nematodes in free-ranging NHPs found within four selected urban and peri-urban centres in Kenya. Methods: A total of 86 NHPs: 41 African green monkeys [AGMs] (Chlorocebus aethiops), 30 olive baboons (Papio anubis), 5 blue monkeys (Cercopithecus mitis stuhlmanni) and 10 red-tailed monkeys (Cercopithecus ascanius) were sampled once in situ and released back to their habitat. Microscopy was used to identify nematodes egg and larvae stages in the samples. Subsequently, PCR coupled with high-resolution melting (PCR-HRM) analysis and sequencing were used to identify nodule worms. Results: NHPs inhabiting densely populated urban environs in Kenya were found infected with a rich diversity of nematodes including three potentially zoonotic nematodes including Oesophagostomum stephanostomum, Oesophagostomum bifurcum and Trichostrongylus colubriformis and co-infections were common. Conclusion: Phylogenetic analysis showed that O. stephanostomum from red-tailed and blue monkeys have a close evolutionary relatedness to human isolates suggesting the zoonotic potential of this parasite. Moreover, we also report the first natural co-infection of O. bifurcum and O. stephanostomum in free-ranging AGMs.en
dc.description.notesThe Consortium for National Health Research (CNHR) grant, Kenya; Global Enhancement Fund grant, USA (2017)en
dc.description.sponsorshipConsortium for National Health Research (CNHR) grant, Kenya; Global Enhancement Fund grant, USA (2017)en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1002/vms3.424en
dc.identifier.eissn2053-1095en
dc.identifier.pmid33400394en
dc.identifier.urihttp://hdl.handle.net/10919/103658en
dc.language.isoenen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectnon-human primatesen
dc.subjectOesophagostomumen
dc.subjectPCR-HRMen
dc.subjecturbanen
dc.subjectzoonosesen
dc.titlePotentially zoonotic gastrointestinal nematodes co-infecting free ranging non-human primates in Kenyan urban centresen
dc.title.serialVeterinary Medicine and Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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