Measurement of serum carboxyterminal cross-linked telopeptide of type I collagen concentration in dogs with osteosarcoma

Simple item page
dc.contributor.authorHintermeister, John G.en
dc.contributor.authorJones, Pamela D.en
dc.contributor.authorHoffmann, Walter E.en
dc.contributor.authorSiegel, Arthur M.en
dc.contributor.authorDervisis, Nikolaos G.en
dc.contributor.authorKitchell, Barbara E.en
dc.date.accessioned2016-11-15T20:48:45Zen
dc.date.available2016-11-15T20:48:45Zen
dc.date.issued2008-11-01en
dc.description.abstractObjective—To evaluate the usefulness of carboxyterminal cross-linked telopeptide of type I collagen (ICTP) concentrations for screening dogs for the presence of osteosarcoma. Sample Population—32 client-owned dogs with osteosarcoma (27 dogs with osteosarcoma of the appendicular skeleton and 5 dogs with osteosarcoma of the axial skeleton) and 44 non–tumor-bearing control dogs. Procedures—Serum was obtained from blood samples collected from dogs with osteosarcoma and from clinically normal dogs. The serum ICTP concentration was determined by use of a commercially available radioimmunoassay for ICTP. Results—Mean ± SD serum ICTP concentration in the tumor-bearing dogs was 7.32 ± 2.88 ng/mL, and in clinically normal dogs, it was 6.77 ± 2.31 ng/mL; values did not differ significantly. Mean serum ICTP concentration in dogs with appendicular osteosarcoma, compared with that of clinically normal dogs, was not significantly different. Mean serum ICTP concentration in dogs with axial skeletal tumor location was 10.82 ± 2.31 ng/mL, compared with a value of 6.73 ± 2.28 ng/mL in dogs with appendicular osteosarcoma. Conclusions and Clinical Relevance—On the basis of the results of this study, serum ICTP concentrations are not a clinically useful screening tool for the detection of appendicular osteosarcoma in dogs. Despite the observation that serum ICTP concentration was higher in dogs with axial osteosarcoma than in clinically normal dogs, serum ICTP concentration determination is not a suitable screening test for osteosarcoma.en
dc.description.versionPublished versionen
dc.format.extent1481 - 1486 (6) page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.2460/ajvr.69.11.1481en
dc.identifier.issn0002-9645en
dc.identifier.issue11en
dc.identifier.urihttp://hdl.handle.net/10919/73454en
dc.identifier.volume69en
dc.language.isoenen
dc.publisherAmerican Veterinary Medical Associationen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000260483800013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectVeterinary Sciencesen
dc.subjectPRIMARY RIB TUMORSen
dc.subjectBONE METABOLISMen
dc.subjectAPPENDICULAR OSTEOSARCOMAen
dc.subjectBIOCHEMICAL MARKERSen
dc.subjectLUNG-CARCINOMAen
dc.subjectMULTIPLE-MYELOMAen
dc.subjectURINARY MARKERSen
dc.subjectN-TELOPEPTIDEen
dc.subjectC-TELOPEPTIDEen
dc.subjectTURNOVERen
dc.titleMeasurement of serum carboxyterminal cross-linked telopeptide of type I collagen concentration in dogs with osteosarcomaen
dc.title.serialAmerican Journal of Veterinary Researchen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Veterinary Medicineen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/CVM T&R Facultyen
pubs.organisational-group/Virginia Tech/Veterinary Medicine/Small Animal Clinical Sciencesen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Measurement of serum carboxyterminal cross-linked telopeptide of type I collagen concentration in dogs with osteosarcoma.pdf
Size:
814.48 KB
Format:
Adobe Portable Document Format
Description:
Publisher's Version
Download
License bundle
Now showing 1 - 1 of 1
Name:
VTUL_Distribution_License_2016_05_09.pdf
Size:
18.09 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

All Faculty Deposits
Scholarly Works, Small Animal Clinical Sciences