Nonparametric Bayesian Functional Clustering with Applications to Racial Disparities in Breast Cancer

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dc.contributor.authorGao, Wenyuen
dc.contributor.authorKim, Inyoungen
dc.contributor.authorNam, Wonilen
dc.contributor.authorRen, Xiangen
dc.contributor.authorZhou, Weien
dc.contributor.authorAgah, Masouden
dc.date.accessioned2024-02-22T14:08:23Zen
dc.date.available2024-02-22T14:08:23Zen
dc.date.issued2024-01en
dc.description.abstractAs we have easier access to massive data sets, functional analyses have gained more interest. However, such data sets often contain large heterogeneities, noises, and dimensionalities. When generalizing the analyses from vectors to functions, classical methods might not work directly. This paper considers noisy information reduction in functional analyses from two perspectives: functional clustering to group similar observations and thus reduce the sample size and functional variable selection to reduce the dimensionality. The complicated data structures and relations can be easily modeled by a Bayesian hierarchical model due to its flexibility. Hence, this paper proposes a nonparametric Bayesian functional clustering and peak point selection method via weighted Dirichlet process mixture (WDPM) modeling that automatically clusters and provides accurate estimations, together with conditional Laplace prior, which is a conjugate variable selection prior. The proposed method is named WDPM-VS for short, and is able to simultaneously perform the following tasks: (1) Automatic cluster without specifying the number of clusters or cluster centers beforehand; (2) Cluster for heterogeneously behaved functions; (3) Select vibrational peak points; and (4) Reduce noisy information from the two perspectives: sample size and dimensionality. The method will greatly outperform its comparison methods in root mean squared errors. Based on this proposed method, we are able to identify biological factors that can explain the breast cancer racial disparities.en
dc.description.versionPublished versionen
dc.format.extent14 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN e11657 (Article number)en
dc.identifier.doihttps://doi.org/10.1002/sam.11657en
dc.identifier.eissn1932-1872en
dc.identifier.issn1932-1864en
dc.identifier.issue1en
dc.identifier.orcidZhou, Wei [0000-0002-5257-3885]en
dc.identifier.orcidAgah, Masoud [0000-0001-6117-4539]en
dc.identifier.urihttps://hdl.handle.net/10919/118109en
dc.identifier.volume17en
dc.language.isoenen
dc.publisherWileyen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectfunctional clusteringen
dc.subjectnonparametric Bayesian modelen
dc.subjectpeak point selectionen
dc.subjectsurface-enhanced Raman spectroscopyen
dc.subjectWDPM-VSen
dc.subjectweighted Dirichlet process mixtureen
dc.titleNonparametric Bayesian Functional Clustering with Applications to Racial Disparities in Breast Canceren
dc.title.serialStatistical Analysis and Data Miningen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dcterms.dateAccepted2023-12-15en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Statisticsen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/Engineering/Electrical and Computer Engineeringen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen

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