An Implantable Micro-Caged Device for Direct Local Delivery of Agents

Simple item page
dc.contributor.authorSon, Alexander I.en
dc.contributor.authorOpfermann, Justin D.en
dc.contributor.authorMccue, Carolineen
dc.contributor.authorZiobro, Julieen
dc.contributor.authorAbrahams, John H., IIIen
dc.contributor.authorJones, Katherineen
dc.contributor.authorMorton, Paul D.en
dc.contributor.authorIshii, Seijien
dc.contributor.authorOluigbo, Chimaen
dc.contributor.authorKrieger, Axelen
dc.contributor.authorLiu, Judy S.en
dc.contributor.authorHashimoto-Torii, Kazueen
dc.contributor.authorTorii, Masaakien
dc.date.accessioned2019-01-02T15:41:29Zen
dc.date.available2019-01-02T15:41:29Zen
dc.date.issued2017-12-15en
dc.description.abstractLocal and controlled delivery of therapeutic agents directly into focally afflicted tissues is the ideal for the treatment of diseases that require direct interventions. However, current options are obtrusive, difficult to implement, and limited in their scope of utilization; the optimal solution requires a method that may be optimized for available therapies and is designed for exact delivery. To address these needs, we propose the Biocage, a customizable implantable local drug delivery platform. The device is a needle-sized porous container capable of encasing therapeutic molecules and matrices of interest to be eluted into the region of interest over time. The Biocage was fabricated using the Nanoscribe Photonic Professional GT 3D laser lithography system, a two-photon polymerization (2PP) 3D printer capable of micron-level precision on a millimeter scale. We demonstrate the build consistency and features of the fabricated device; its ability to release molecules; and a method for its accurate, stable delivery in mouse brain tissue. The Biocage provides a powerful tool for customizable and precise delivery of therapeutic agents into target tissues.en
dc.description.notesWe would like to thank Terrapin Works (School of Engineering, University of Maryland, College Park, MD 20740) for aiding in printing the Biocage, and the Nanocenter FabLab (University of Maryland, College Park, MD 20742) for aiding in imaging the Biocage. Microscopic analysis was carried out at the Children's Research Institute (CRI) Light Microscopy and Image Analysis Core supported by CRI and NIH grant P30HD040677. This work was supported by the National Institute of Health (R01 MH111674) (M.T.), the Scott-Gentle Foundation (M.T. and K.H.-T.), the Brain & Behavior Research Foundation, and Whitehall Foundation (J.L.). This project was also supported by Award Number UL1TR001876 from the NIH National Center for Advancing Translational Sciences (M.T. and K.H.-T.). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Center for Advancing Translational Sciences or the National Institutes of Health.en
dc.description.sponsorshipNIH [P30HD040677]; National Institute of Health [R01 MH111674]; Scott-Gentle Foundation; Brain & Behavior Research Foundation; Whitehall Foundation; NIH National Center for Advancing Translational Sciences [UL1TR001876]en
dc.format.extent16 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/s41598-017-17912-yen
dc.identifier.issn2045-2322en
dc.identifier.other17624en
dc.identifier.pmid29247175en
dc.identifier.urihttp://hdl.handle.net/10919/86541en
dc.identifier.volume7en
dc.language.isoenen
dc.publisherSpringer Natureen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectcentral-nervous-systemen
dc.subjectocular drug-deliveryen
dc.subjectblood-brain-barrieren
dc.subjectbiomedical applicationsen
dc.subjectparkinsons-diseaseen
dc.subjectalzheimers-diseaseen
dc.subjectgrowth-factoren
dc.subjectcell therapyen
dc.subjectstrategiesen
dc.subjectmedicineen
dc.titleAn Implantable Micro-Caged Device for Direct Local Delivery of Agentsen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
s41598-017-17912-y.pdf
Size:
6.51 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Scholarly Works, Biomedical Sciences and Pathobiology