Plasma SOMAmer proteomics of postoperative delirium

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dc.contributor.authorLeung, Jacqueline M.en
dc.contributor.authorRojas, Julio C.en
dc.contributor.authorSands, Laura P.en
dc.contributor.authorChan, Brandonen
dc.contributor.authorRajbanshi, Binitaen
dc.contributor.authorDu, Zhiyuanen
dc.contributor.authorDu, Pangen
dc.date.accessioned2025-02-07T18:30:31Zen
dc.date.available2025-02-07T18:30:31Zen
dc.date.issued2024-02-12en
dc.description.abstractBackground: Postoperative delirium is prevalent in older adults and has been shown to increase the risk of long-term cognitive decline. Plasma biomarkers to identify the risk for postoperative delirium and the risk of Alzheimer's disease and related dementias are needed. Methods: This biomarker discovery case–control study aimed to identify plasma biomarkers associated with postoperative delirium. Patients aged ≥65 years undergoing major elective noncardiac surgery were recruited. The preoperative plasma proteome was interrogated with SOMAmer-based technology targeting 1433 biomarkers. Results: In 40 patients (20 with vs. 20 without postoperative delirium), a preoperative panel of 12 biomarkers discriminated patients with postoperative delirium with an accuracy of 97.5%. The final model of five biomarkers delivered a leave-one-out cross-validation accuracy of 80%. Represented biological pathways included lysosomal and immune response functions. Conclusion: In older patients who have undergone major surgery, plasma SOMAmer proteomics may provide a relatively non-invasive benchmark to identify biomarkers associated with postoperative delirium.en
dc.description.versionPublished versionen
dc.format.extent9 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN e3422 (Article number)en
dc.identifier.doihttps://doi.org/10.1002/brb3.3422en
dc.identifier.eissn2162-3279en
dc.identifier.issn2162-3279en
dc.identifier.issue2en
dc.identifier.orcidSands, Laura [0000-0003-2446-4486]en
dc.identifier.orcidDu, Pang [0000-0003-1365-4831]en
dc.identifier.otherPMC10861352en
dc.identifier.pmid38346717en
dc.identifier.urihttps://hdl.handle.net/10919/124535en
dc.identifier.volume14en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/38346717en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectbiomarkersen
dc.subjectpostoperative deliriumen
dc.subjectproteomicsen
dc.subject.meshHumansen
dc.subject.meshDeliriumen
dc.subject.meshPostoperative Complicationsen
dc.subject.meshCase-Control Studiesen
dc.subject.meshProteomicsen
dc.subject.meshAgeden
dc.subject.meshBiomarkersen
dc.subject.meshEmergence Deliriumen
dc.titlePlasma SOMAmer proteomics of postoperative deliriumen
dc.title.serialBrain and Behavioren
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2024-01-22en
pubs.organisational-groupVirginia Techen
pubs.organisational-groupVirginia Tech/Scienceen
pubs.organisational-groupVirginia Tech/Science/Statisticsen
pubs.organisational-groupVirginia Tech/Faculty of Health Sciencesen
pubs.organisational-groupVirginia Tech/All T&R Facultyen
pubs.organisational-groupVirginia Tech/Science/COS T&R Facultyen
pubs.organisational-groupVirginia Tech/VT Carilion School of Medicineen
pubs.organisational-groupVirginia Tech/Liberal Arts and Human Sciencesen
pubs.organisational-groupVirginia Tech/Liberal Arts and Human Sciences/CLAHS T&R Facultyen
pubs.organisational-groupVirginia Tech/VT Carilion School of Medicine/Basic Scienceen
pubs.organisational-groupVirginia Tech/VT Carilion School of Medicine/Basic Science/Basic Scienceen
pubs.organisational-groupVirginia Tech/VT Carilion School of Medicine/Basic Science/Basic Science/Secondary Appointment-Basic Scienceen
pubs.organisational-groupVirginia Tech/VT Carilion School of Medicine/Basic Science/Secondary Appointment-Basic Scienceen

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