A paternal methyl donor depleted diet leads to increased anxiety- and depression-like behavior in adult rat offspring

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dc.contributor.authorMcCoy, Chelsea R.en
dc.contributor.authorJackson, Nateka L.en
dc.contributor.authorBrewer, Rachel L.en
dc.contributor.authorMoughnyeh, Mohamad M.en
dc.contributor.authorSmith, Daniel L.en
dc.contributor.authorClinton, Sarah M.en
dc.date.accessioned2021-10-20T12:06:36Zen
dc.date.available2021-10-20T12:06:36Zen
dc.date.issued2018-08-31en
dc.date.updated2021-10-20T12:06:33Zen
dc.description.abstractEpigenetic mechanisms such as DNA methylation elicit lasting changes in gene expression and likely mediate gene–environment interactions that shape brain development, behavior, and emotional health. Myriad environmental factors influence DNA methylation, including methyl donor content in the paternal diet, could influence methylation in offspring via changes in the paternal germ line. The present study examines the effects of paternal methyl donor dietary deficiency on offspring’s emotional behaviors, including anxiety, social interaction, and depression-like behavior. We previously found that rats bred to display high levels of anxiety- and depression-like behavior exhibit diminished DNA methylation in the amygdala. We also observed that depleting dietary methyl donor content exacerbated the rats’ already high levels of anxiety- and depression-like behavior. Here we sought to determine whether paternal dietary methyl donor depletion elicits intergenerational effects on first generation (F1) offspring’s behavior (potentially triggering a similar increase in anxiety- and/or depression-like behavior). Thus, adult male rats prone to high anxiety/depression-like behavior, were fed either a methyl donor depleted (DEP) or control (CON) diet for 5 weeks prior to mating. They were paired with females and resultant F1 male offspring were subjected to a behavioral test battery in adulthood. F1-DEP offspring showed a similar behavioral profile to the F0 males, including greater depression-like behavior in the forced swim test (FST) and increased anxiety-like behavior in the open field test (OFT). Future work will interrogate molecular changes in the brains of F1 offspring that mediate these intergenerational effects of paternal methyl donor dietary content on offspring emotional behavior.en
dc.description.versionPublished versionen
dc.format.extent8 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN BSR20180730 (Article number)en
dc.identifier.doihttps://doi.org/10.1042/BSR20180730en
dc.identifier.eissn1573-4935en
dc.identifier.issn0144-8463en
dc.identifier.issue4en
dc.identifier.orcidMcCoy Asadorian, Chelsea [0000-0001-7807-7524]en
dc.identifier.orcidClinton, Sarah [0000-0001-7158-411X]en
dc.identifier.otherBSR20180730 (PII)en
dc.identifier.pmid29945927en
dc.identifier.urihttp://hdl.handle.net/10919/105424en
dc.identifier.volume38en
dc.language.isoenen
dc.publisherPortland Pressen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000449560000019&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectLife Sciences & Biomedicineen
dc.subjectBiochemistry & Molecular Biologyen
dc.subjectCell Biologyen
dc.subjectDNA METHYLATIONen
dc.subjectNOVELTY-SEEKINGen
dc.subjectSEX-DIFFERENCESen
dc.subjectEPIGENETIC REGULATIONen
dc.subjectRESPONDER RATSen
dc.subjectDEFICIENT DIETen
dc.subjectBRAINen
dc.subjectEXPRESSIONen
dc.subjectAMYGDALAen
dc.subjectSTRESSen
dc.subjectAnxietyen
dc.subjectDNA Methylationen
dc.subjectDepressionen
dc.subjectDieten
dc.subjectEpigeneticsen
dc.subject0601 Biochemistry and Cell Biologyen
dc.subject.meshAnimalsen
dc.subject.meshRatsen
dc.subject.meshPrenatal Exposure Delayed Effectsen
dc.subject.meshDieten
dc.subject.meshBehavior, Animalen
dc.subject.meshDepressionen
dc.subject.meshAnxietyen
dc.subject.meshPaternal Exposureen
dc.subject.meshDNA Methylationen
dc.subject.meshEpigenesis, Geneticen
dc.subject.meshPregnancyen
dc.subject.meshAnimal Feeden
dc.subject.meshFemaleen
dc.subject.meshMaleen
dc.titleA paternal methyl donor depleted diet leads to increased anxiety- and depression-like behavior in adult rat offspringen
dc.title.serialBioscience Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2018-06-25en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/Science/School of Neuroscienceen
pubs.organisational-group/Virginia Tech/Post-docsen

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