Choosing Money over Drugs: The Neural Underpinnings of Difficult Choice in Chronic Cocaine Users

dc.contributor.authorWesley, Michael J.en
dc.contributor.authorLohrenz, Terryen
dc.contributor.authorKoffarnus, Mikhail N.en
dc.contributor.authorMcClure, Samuel M.en
dc.contributor.authorDe La Garza, Richard IIen
dc.contributor.authorSalas, Ramiroen
dc.contributor.authorThompson-Lake, Daisy G. Y.en
dc.contributor.authorNewton, Thomas F.en
dc.contributor.authorBickel, Warren K.en
dc.contributor.authorMontague, P. Readen
dc.date.accessioned2017-09-18T09:44:12Zen
dc.date.available2017-09-18T09:44:12Zen
dc.date.issued2014-08-14en
dc.date.updated2017-09-18T09:44:12Zen
dc.description.abstractAddiction is considered a disorder that drives individuals to choose drugs at the expense of healthier alternatives. However, chronic cocaine users (CCUs)who meet addiction criteria retain the ability to choose money in the presence of the opportunity to choose cocaine. The neural mechanisms that differentiate CCUs from non-cocaine using controls (Controls) while executing these preferred choices remain unknown. Thus, therapeutic strategies aimed at shifting preferences towards healthier alternatives remain somewhat uninformed. This study used BOLD neuroimaging to examine brain activity as fifty CCUs and Controls performed single- and cross-commodity intertemporal choice tasks for money and/or cocaine. Behavioral analyses revealed preferences for each commodity type. Imaging analyses revealed the brain activity that differentiated CCUs from Controls while choosing money over cocaine. We observed thatCCUs devalued future commodities more than Controls. Choices for money as opposed to cocaine correlated with greater activity in dorsal striatum of CCUs, compared to Controls. In addition, choices for future money as opposed to immediate cocaine engaged the left dorsolateral prefrontal cortex (DLPFC) of CCUs more than Controls. These data suggest that the ability of CCUs to execute choices away from cocaine relies on activity in the dorsal striatum and left DLPFC.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMichael J. Wesley, Terry Lohrenz, Mikhail N. Koffarnus, et al., “Choosing Money over Drugs: The Neural Underpinnings of Difficult Choice in Chronic Cocaine Users,” Journal of Addiction, vol. 2014, Article ID 189853, 14 pages, 2014. doi:10.1155/2014/189853en
dc.identifier.doihttps://doi.org/10.1155/2014/189853en
dc.identifier.urihttp://hdl.handle.net/10919/78971en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2014 Michael J. Wesley et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleChoosing Money over Drugs: The Neural Underpinnings of Difficult Choice in Chronic Cocaine Usersen
dc.title.serialJournal of Addictionen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
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