Biodegradable Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19 and Anti-Multidrug Resistant Bacteria Evaluation

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dc.contributor.authorAlshabanah, Latifah Abdullahen
dc.contributor.authorHagar, Mohameden
dc.contributor.authorAl-Mutabagani, Laila A.en
dc.contributor.authorAbozaid, Ghada M.en
dc.contributor.authorAbdallah, Salwa M.en
dc.contributor.authorAhmed, Hodaen
dc.contributor.authorHassanin, Ahmed H.en
dc.contributor.authorShehata, Naderen
dc.contributor.departmentElectrical and Computer Engineeringen
dc.date.accessioned2021-07-23T17:27:06Zen
dc.date.available2021-07-23T17:27:06Zen
dc.date.issued2021-07-10en
dc.date.updated2021-07-23T13:27:01Zen
dc.description.abstractBiodegradable nanofibrous hybrid membranes of polyvinyl alcohol (PVA) with ZnO and CuO nanoparticles were manufactured and characterized, and their anti-COVID-19 and anti-multidrug resistant bacteria activities were also evaluated. The morphological structures of the prepared PVA composites nanofibers were observed by scanning electron microscope (SEM), which revealed a homogenous pattern of the developed nanofibers, with an average fibrous diameter of 200–250 nm. Moreover, the results of the SEM showed that the fiber size changed with the type and the concentration of the metal oxide. Moreover, the antiviral and antibacterial potential capabilities of the developed nanofibrous membranes were tested in blocking the viral fusion of SARS-COV-2, as a representative activity for COVID-19 deactivation, as well as for their activity against a variety of bacterial strains, including multi-drug resistant bacteria (MDR). The results revealed that ZnO loaded nanofibers were more potent antiviral agents than their CuO analogues. This antiviral action was attributed to the fact that inorganic metallic compounds have the ability to extract hydrogen bonds with viral proteins, causing viral rupture or morphological changes. On the other hand, the anti-multi-drug resistant activity of the prepared nanofibers was also evaluated using two techniques; the standard test method for determining the antimicrobial activity of immobilized antimicrobial agents under dynamic contact conditions and the standard test method for determining the activity of incorporated antimicrobial agents in polymeric or hydrophobic materials. Both techniques proved the superiority of the ZnO loaded nanofibers over the CuO loaded fibers. The results of the antiviral and antibacterial tests showed the effectiveness of such nanofibrous formulas, not only for medical applications, but also for the production of personal protection equipment, such as gowns and textiles.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAlshabanah, L.A.; Hagar, M.; Al-Mutabagani, L.A.; Abozaid, G.M.; Abdallah, S.M.; Ahmed, H.; Hassanin, A.H.; Shehata, N. Biodegradable Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19 and Anti-Multidrug Resistant Bacteria Evaluation. Materials 2021, 14, 3862.en
dc.identifier.doihttps://doi.org/10.3390/ma14143862en
dc.identifier.urihttp://hdl.handle.net/10919/104372en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectbiodegradable nanofibrous membraneen
dc.subjectPVA-ZnO or -CuO nanohybridsen
dc.subjectanti-COVID-19 nanofibersen
dc.subjectanti-multi-drug resistant bacterial nanofibersen
dc.titleBiodegradable Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19 and Anti-Multidrug Resistant Bacteria Evaluationen
dc.title.serialMaterialsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Journal Articles, Multidisciplinary Digital Publishing Institute (MDPI)
Destination Area: Global Systems Science (GSS)
Scholarly Works, Electrical and Computer Engineering