Unique features of a global human ectoparasite identified through sequencing of the bed bug genome

Simple item page
dc.contributor.authorBenoit, Joshua B.en
dc.contributor.authorAdelman, Zach N.en
dc.contributor.authorReinhardt, Klausen
dc.contributor.authorDolan, Amanda M.en
dc.contributor.authorPoelchau, Monicaen
dc.contributor.authorJennings, Emily C.en
dc.contributor.authorSzuter, Elise M.en
dc.contributor.authorHagan, Richard W.en
dc.contributor.authorGujar, Hemanten
dc.contributor.authorShukla, Jayendra Nathen
dc.contributor.authorZhu, Fangen
dc.contributor.authorMohan, M.en
dc.contributor.authorNelson, David R.en
dc.contributor.authorRosendale, Andrew J.en
dc.contributor.authorDerst, Christianen
dc.contributor.authorResnik, Valentinaen
dc.contributor.authorWernig, Sebastianen
dc.contributor.authorMenegazzi, Pamelaen
dc.contributor.authorWegener, Christianen
dc.contributor.authorPeschel, Nicolaien
dc.contributor.authorHendershot, Jacob M.en
dc.contributor.authorBlenau, Wolfgangen
dc.contributor.authorPredel, Reinharden
dc.contributor.authorJohnston, Paul R.en
dc.contributor.authorIoannidis, Panagiotisen
dc.contributor.authorWaterhouse, Robert M.en
dc.contributor.authorNauen, Ralfen
dc.contributor.authorSchorn, Corinnaen
dc.contributor.authorOtt, Mark-Christophen
dc.contributor.authorMaiwald, Franken
dc.contributor.authorJohnston, J. Spenceren
dc.contributor.authorGondhalekar, Ameya D.en
dc.contributor.authorScharf, Michael E.en
dc.contributor.authorPeterson, Brittany F.en
dc.contributor.authorRaje, Kapil R.en
dc.contributor.authorHottel, Benjamin A.en
dc.contributor.authorArmisen, Daviden
dc.contributor.authorCrumiere, Antonin Jean Johanen
dc.contributor.authorRefki, Peter Naguien
dc.contributor.authorSantos, Maria Emiliaen
dc.contributor.authorSghaier, Essiaen
dc.contributor.authorViala, Severineen
dc.contributor.authorKhila, Abderrahmanen
dc.contributor.authorAhn, Seung-Joonen
dc.contributor.authorChilders, Christopheren
dc.contributor.authorLee, Chien-Yuehen
dc.contributor.authorLin, Hanen
dc.contributor.authorHughes, Daniel S. T.en
dc.contributor.authorDuncan, Elizabeth J.en
dc.contributor.authorMurali, Shwetha C.en
dc.contributor.authorQu, Jiaxinen
dc.contributor.authorDugan, Shannonen
dc.contributor.authorLee, Sandra L.en
dc.contributor.authorChao, Hsuen
dc.contributor.authorDinh, Huyenen
dc.contributor.authorHan, Yien
dc.contributor.authorDoddapaneni, Harshavardhanen
dc.contributor.authorWorley, Kim C.en
dc.contributor.authorMuzny, Donna M.en
dc.contributor.authorWheeler, Daviden
dc.contributor.authorPanfilio, Kristen A.en
dc.contributor.authorJentzsch, Iris M. Vargasen
dc.contributor.authorVargo, Edward L.en
dc.contributor.authorBooth, Warrenen
dc.contributor.authorFriedrich, Markusen
dc.contributor.authorWeirauch, Matthew T.en
dc.contributor.authorAnderson, Michelle A. E.en
dc.contributor.authorJones, Jeffery W.en
dc.contributor.authorMittapalli, Omprakashen
dc.contributor.authorZhao, Chaoyangen
dc.contributor.authorZhou, Jing-Jiangen
dc.contributor.authorEvans, Jay D.en
dc.contributor.authorAttardo, Geoffrey M.en
dc.contributor.authorRobertson, Hugh M.en
dc.contributor.authorZdobnov, Evgeny M.en
dc.contributor.authorRibeiro, Jose M. C.en
dc.contributor.authorGibbs, Richard A.en
dc.contributor.authorWerren, John H.en
dc.contributor.authorPalli, Subba R.en
dc.contributor.authorSchal, Cobyen
dc.contributor.authorRichards, Stephenen
dc.contributor.departmentEntomologyen
dc.date.accessioned2017-11-13T19:43:18Zen
dc.date.available2017-11-13T19:43:18Zen
dc.date.issued2016-02-02en
dc.description.abstractThe bed bug, Cimex lectularius, has re-established itself as a ubiquitous human ectoparasite throughout much of the world during the past two decades. This global resurgence is likely linked to increased international travel and commerce in addition to widespread insecticide resistance. Analyses of the C. lectularius sequenced genome (650Mb) and 14,220 predicted protein-coding genes provide a comprehensive representation of genes that are linked to traumatic insemination, a reduced chemosensory repertoire of genes related to obligate hematophagy, host–symbiont interactions, and several mechanisms of insecticide resistance. In addition, we document the presence of multiple putative lateral gene transfer events. Genome sequencing and annotation establish a solid foundation for future research on mechanisms of insecticide resistance, human–bed bug and symbiont–bed bug associations, and unique features of bed bug biology that contribute to the unprecedented success of C. lectularius as a human ectoparasiteen
dc.description.sponsorshipFunding for genome sequencing, assembly and automated annotation was provided by NHGRI grant U54 HG003273 to R.A.G. Funding for bed bug lines development was provided by Blanton J. Whitmire endowment, Housing and Urban Development (NCHHU-00017-13), National Science Foundation (IOS-1052238), Alfred P. Sloan Foundation (2013-5-35 MBE) to Cob. S. Funding for preparation of genomic DNA and RNA for sequencing and for manual curation of some of the genes was provided by NIH (GM070559-9) to S.R.P. Funding for manual curation and other analyses were provided by the Royal Society of New Zealand Marsden Fast Start Grant (11-UOO-124) to E.J.D., Fralin Life Sciences Institutes and Virginia Agriculture Experimental Station to Z.N.A., European Research Council (ERC-CoG 616346) to A.K., Deutsche Forschungsgemeinschaft (DFG): Pe1798/2-1 to N.P., Deutsche Forschungsgemeinschaft (DFG): PA2044/1-1 to K.A.P., Deutsche Forschungsgemeinschaft (DFG): collaborative research center SFB 1047 ‘Insect timing,’ Project A1 to P.M., The Zukunftskonzept at TU Dresden funded by the Exzellenzinitiative of the Deutsche Forschungsgemeinschaft to K.R., Deutsche Forschungsgemeinschaft (DFG): BL469/7-1 to Wo.B., Deutsche Forschungsgemeinschaft (DFG): 766/11-1 to R.P., European Research Council grant 260986 to P.J., Biotechnology and Biological Sciences Research Council to J.-J.Z., University of Cincinnati Faculty Development Research Grant and Ohio Supercomputer Center Research Allocation to J.B.B., Marie Curie International Outgoing Fellowship PIOF-GA- 2011–303312 to R.M.W., National Science Foundation (DEB-1257053) to J.H.W., and Swiss National Science Foundation awards 31003A-125350 and 31003A-143936 to E.M.Z..en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/ncomms10165en
dc.identifier.issn2041-1723en
dc.identifier.pmid26836814en
dc.identifier.urihttp://hdl.handle.net/10919/80353en
dc.identifier.volume7en
dc.language.isoenen
dc.publisherNatureen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleUnique features of a global human ectoparasite identified through sequencing of the bed bug genomeen
dc.title.serialNature Communicationsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
BenoitBedbug2016.pdf
Size:
1020.12 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Scholarly Works, Entomology