The Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic View

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dc.contributor.authorXavier, Joao B.en
dc.contributor.authorYoung, Vincent B.en
dc.contributor.authorSkufca, Josephen
dc.contributor.authorGinty, Fionaen
dc.contributor.authorTesterman, Tracien
dc.contributor.authorPearson, Alexander T.en
dc.contributor.authorMacklin, Paulen
dc.contributor.authorMitchell, Amiren
dc.contributor.authorShmulevich, Ilyaen
dc.contributor.authorXie, Leien
dc.contributor.authorCaporaso, J. Gregoryen
dc.contributor.authorCrandall, Keith A.en
dc.contributor.authorSimone, Nicole L.en
dc.contributor.authorGodoy-Vitorino, Filipaen
dc.contributor.authorGriffin, Timothy J.en
dc.contributor.authorWhiteson, Katrine L.en
dc.contributor.authorGustafson, Heather H.en
dc.contributor.authorSlade, Daniel J.en
dc.contributor.authorSchmidt, Thomas M.en
dc.contributor.authorWalther-Antonio, Marina RS S.en
dc.contributor.authorKorem, Talen
dc.contributor.authorWebb-Robertson, Bobbie-Jo M.en
dc.contributor.authorStyczynski, Mark P.en
dc.contributor.authorJohnson, W. Evanen
dc.contributor.authorJobin, Christianen
dc.contributor.authorRidlon, Jason M.en
dc.contributor.authorKoh, Andrew Y.en
dc.contributor.authorYu, Michaelen
dc.contributor.authorKelly, Libushaen
dc.contributor.authorWargo, Jennifer A.en
dc.contributor.departmentBiochemistryen
dc.date.accessioned2021-09-27T15:00:46Zen
dc.date.available2021-09-27T15:00:46Zen
dc.date.issued2020-03-01en
dc.date.updated2021-09-27T15:00:42Zen
dc.description.abstractThe collection of microbes that live in and on the human body – the human microbiome – can impact on cancer initiation, progression, and response to therapy, including cancer immunotherapy. The mechanisms by which microbiomes impact on cancers can yield new diagnostics and treatments, but much remains unknown. The interactions between microbes, diet, host factors, drugs, and cell–cell interactions within the cancer itself likely involve intricate feedbacks, and no single component can explain all the behavior of the system. Understanding the role of host-associated microbial communities in cancer systems will require a multidisciplinary approach combining microbial ecology, immunology, cancer cell biology, and computational biology – a systems biology approach.en
dc.description.versionPublished versionen
dc.format.extentPages 192-204en
dc.format.extent13 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.trecan.2020.01.004en
dc.identifier.eissn2405-8033en
dc.identifier.issn2405-8025en
dc.identifier.issue3en
dc.identifier.orcidSlade, Daniel [0000-0001-5634-7220]en
dc.identifier.otherS2405-8033(20)30017-0 (PII)en
dc.identifier.pmid32101723en
dc.identifier.urihttp://hdl.handle.net/10919/105085en
dc.identifier.volume6en
dc.language.isoenen
dc.publisherCell Pressen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000517798700005&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectLife Sciences & Biomedicineen
dc.subjectOncologyen
dc.subjectHUMAN GUT MICROBIOTAen
dc.subjectSPATIAL-ORGANIZATIONen
dc.subjectHELICOBACTER-PYLORIen
dc.subjectMETABOLISMen
dc.subjectEFFICACYen
dc.subjectTHERAPYen
dc.subjectRISKen
dc.subjectPERSISTENCEen
dc.subjectRESISTANCEen
dc.subjectIPILIMUMABen
dc.subject1112 Oncology and Carcinogenesisen
dc.subject.meshCentral Nervous Systemen
dc.subject.meshAnimalsen
dc.subject.meshHumansen
dc.subject.meshMiceen
dc.subject.meshBacteriaen
dc.subject.meshOncogenic Virusesen
dc.subject.meshHelicobacter Infectionsen
dc.subject.meshTumor Virus Infectionsen
dc.subject.meshNeoplasmsen
dc.subject.meshStomach Neoplasmsen
dc.subject.meshGastritisen
dc.subject.meshAnalgesics, Opioiden
dc.subject.meshImmunotherapyen
dc.subject.meshEnvironmental Microbiologyen
dc.subject.meshSymbiosisen
dc.subject.meshDrug Synergismen
dc.subject.meshProbioticsen
dc.subject.meshHost-Pathogen Interactionsen
dc.subject.meshMicrobiotaen
dc.subject.meshGastrointestinal Microbiomeen
dc.titleThe Cancer Microbiome: Distinguishing Direct and Indirect Effects Requires a Systemic Viewen
dc.title.serialTrends in Canceren
dc.typeArticleen
dc.type.dcmitypeTexten
dc.type.otherJournalen
dcterms.dateAccepted2020-01-06en
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciencesen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/Biochemistryen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Agriculture & Life Sciences/CALS T&R Facultyen

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