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Common differentially expressed genes and pathways correlating both coronary artery disease and atrial fibrillation

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dc.contributor.authorZheng, Youjingen
dc.contributor.authorHe, Jia-Qiangen
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.date.accessioned2021-06-10T18:36:15Zen
dc.date.available2021-06-10T18:36:15Zen
dc.date.issued2021-05-03en
dc.description.abstractCoronary artery disease (CAD) and atrial fibrillation (AF) share common risk factors, such as hypertension and diabetes. The patients with CAD often suffer concomitantly AF, but how two diseases interact with each other at cellular and molecular levels remain largely unknown. The present study aims to dissect the common differentially expressed genes (DEGs) that are concurrently associated with CAD and AF. Two datasets [GSE71226 for CAD) and GSE31821 for AF] were analyzed with GEO2R and Venn Diagram to identify the DEGs. Signaling pathways, gene enrichments, and protein-protein interactions (PPI) of the identified common DEGs were further analyzed with Kyoto Encyclopedia of Gene and Genome (KEGG), Database for Annotation, Visualization and Integrated Discovery (DAVID), and Search Toll for the Retrieval of Interacting Genes (STRING). 565 up- and 1367 down-regulated genes in GSE71226 and 293 up- and 68 down-regulated genes in GSE31821 were identified. Among those, 21 common DEGs were discovered from both datasets, which lead to the findings of 4 CAD and 21 AF pathways, 3 significant gene enrichments (intracellular cytoplasm, protein binding, and vascular labyrinthine layer), and 3 key proteins (membrane metallo-endopeptidase (MME), transferrin receptor 1 (TfR1), and Lyso-some-associated membrane glycoprotein 1 (LAMP1)). Together, these data implied that these three proteins may play a central role in development of both CAD and AF.en
dc.description.notesThis work was supported by the NIH grant (1R15HL140528-01 for JQH), OneHealth seed grant (PJ6SPVHJ for JQH) by the College of Veterinary Medicine at Virginia Tech and the Edward Via College of Osteopathic Medicine, Interdisciplinary Graduate Education Programs of Regenerative Medicine (IGEP-RM, for YJZ), and IRC Seed Grant (#178391 for JQH) by the College of Veterinary Medicine at Virginia Tech. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.description.sponsorshipNIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [1R15HL140528-01]; College of Veterinary Medicine at Virginia Tech [PJ6SPVHJ]; Edward Via College of Osteopathic Medicine, Interdisciplinary Graduate Education Programs of Regenerative Medicine (IGEP-RM); IRC Seed Grant by the College of Veterinary Medicine at Virginia Tech. [178391]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.17179/excli2020-3262en
dc.identifier.issn1611-2156en
dc.identifier.pmid33564282en
dc.identifier.urihttp://hdl.handle.net/10919/103753en
dc.identifier.volume20en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectCoronary artery diseaseen
dc.subjectatrial fibrillationen
dc.subjectdifferentially expressed geneen
dc.subjectsignaling pathwayen
dc.subjectbioinformaticsen
dc.titleCommon differentially expressed genes and pathways correlating both coronary artery disease and atrial fibrillationen
dc.title.serialEXCLI Journalen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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