Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic Cells

Liao, Xiaofeng; Reihl, Alec M.; Luo, Xin M.

Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic Cells

dc.contributor.author	Liao, Xiaofeng	en
dc.contributor.author	Reihl, Alec M.	en
dc.contributor.author	Luo, Xin M.	en
dc.date.accessioned	2017-09-18T09:38:11Z	en
dc.date.available	2017-09-18T09:38:11Z	en
dc.date.issued	2016-02-29	en
dc.date.updated	2017-09-18T09:38:11Z	en
dc.description.abstract	Dendritic cells (DC) play an important role in the pathogenesis of systemic lupus erythematosus (SLE), an autoimmune disease with multiple tissue manifestations. In this review, we summarize recent studies on the roles of conventional DC and plasmacytoid DC in the development of both murine lupus and human SLE. In the past decade, studies using selective DC depletions have demonstrated critical roles of DC in lupus progression. Comprehensive in vitro and in vivo studies suggest activation of DC by self-antigens in lupus pathogenesis, followed by breakdown of immune tolerance to self. Potential treatment strategies targeting DC have been developed. However, many questions remain regarding the mechanisms by which DC modulate lupus pathogenesis that require further investigations.	en
dc.description.version	Published version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Xiaofeng Liao, Alec M. Reihl, and Xin M. Luo, “Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic Cells,” Journal of Immunology Research, vol. 2016, Article ID 6269157, 15 pages, 2016. doi:10.1155/2016/6269157	en
dc.identifier.doi	https://doi.org/10.1155/2016/6269157	en
dc.identifier.uri	http://hdl.handle.net/10919/78941	en
dc.language.iso	en	en
dc.publisher	Hindawi	en
dc.rights	Creative Commons Attribution 4.0 International	en
dc.rights.holder	Copyright © 2016 Xiaofeng Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.	en
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	en
dc.title	Breakdown of Immune Tolerance in Systemic Lupus Erythematosus by Dendritic Cells	en
dc.title.serial	Journal of Immunology Research	en
dc.type	Article - Refereed	en
dc.type.dcmitype	Text	en