Protective immune response to experimental infection with Sarcocystis neurona in C57BL/6 mice

Simple item page
dc.contributor.authorWitonsky, Sharon G.en
dc.contributor.authorGogal, Robert M.en
dc.contributor.authorDuncan, Robert B.en
dc.contributor.authorLindsay, David S.en
dc.date.accessed2014-06-16en
dc.date.accessioned2014-06-20T14:13:21Zen
dc.date.available2014-06-20T14:13:21Zen
dc.date.issued2003-10en
dc.description.abstractImmunocompetent C57BL/6 mice were infected with Sarcocystis neurona merozoites to assess the protective immune response to active infection. Using a direct agglutination test, all infected mice seroconverted to S. neurona merozoite antigens by day 14 postinfection (PI). Further, mice developed splenomegaly and bilateral symmetrical lymphadenopathy by day 14 PI, which appeared to be resolving by day 28 PI. Histologic analysis revealed a marked increase in germinal center formation in the spleen and lymph nodes by day 14 PI. Corresponding to gross and histopathological changes, the percentage of B-cells decreased significantly by day 14 PI but then increased significantly and persisted at day 28 PI in the blood, spleen, and multiple lymph nodes. There was a sharp nonspecific significant decrease in CD4 percentages by day 14 PI in the blood, spleen, and lymph nodes. Early-activation CD8 lymphocytes (CD62/CD8) were significantly down-regulated coinciding with a significant compensatory up-regulation of memory (CD44/CD8) lymphocytes in multiple organs. We propose that the protective cell-mediated immune response to S. neurona involves both CD4 and CD8 cells, with CD8 lymphocytes appearing to play a more critical role.en
dc.description.sponsorshipCSREES Animal Health and Diseaseen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSharon G. Witonsky, Robert M. Gogal Jr., Robert B. Duncan, and David S. Lindsay (2003). "Protective immune response to experimental infection with Sarcocystis neurona in C57BL/6 mice," Journal of Parasitology: October 2003, Vol. 89, No. 5, pp. 924-931. doi: http://dx.doi.org/10.1645/GE-67Ren
dc.identifier.doihttps://doi.org/10.1645/ge-67ren
dc.identifier.issn0022-3395en
dc.identifier.urihttp://hdl.handle.net/10919/49079en
dc.identifier.urlhttp://www.bioone.org/doi/abs/10.1645/GE-67Ren
dc.language.isoenen
dc.publisherAmerican Society of Parasitologyen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectequine protozoal myeloencephalitisen
dc.subjectnitric-oxideen
dc.subjecttoxoplasma-gondiien
dc.subjectvirusen
dc.subjectMemoryen
dc.subjectencephalomyelitisen
dc.subjectexpressionen
dc.subjectcellsen
dc.subjectparasitologyen
dc.titleProtective immune response to experimental infection with Sarcocystis neurona in C57BL/6 miceen
dc.title.serialJournal of Parasitologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ge-67r.pdf
Size:
975.46 KB
Format:
Adobe Portable Document Format
Description:
Main article
Download

Collections

Scholarly Works, Biomedical Sciences and Pathobiology
Scholarly Works, Large Animal Clinical Sciences