Evaluation of Five Antischizophrenic Agents Against Toxoplasma gondii in Human Cell Cultures

dc.contributor.authorGoodwin, David G.en
dc.contributor.authorStrobl, Jeannine S.en
dc.contributor.authorLindsay, David S.en
dc.contributor.departmentElectrical and Computer Engineeringen
dc.contributor.departmentBiomedical Sciences and Pathobiologyen
dc.date.accessed2014-06-16en
dc.date.accessioned2014-06-20T14:13:13Zen
dc.date.available2014-06-20T14:13:13Zen
dc.date.issued2011-02-01en
dc.description.abstractAn increasing interest in the association of the presence of antibodies to Toxoplasma gondii and the development of schizophrenia in patients has been generated over the last several years. Some antischizophrenia agents have been shown to have activity against T gondii in cell culture assays and to ameliorate behavioral changes associated with chronic T gondii infection in rats. In the present study, we examined the effects of commonly used antipsychotic and mood stabilizing agents (haloperidol, clozapine, fluphenazine, trifluoperazine, and thioridazine) for activity against developing tachyzoites of the RH strain of T. gondii in human fibroblast cell cultures. Neither haloperidol nor clozapine had a measurable effect. Fluphenazine had an IC(50) of 1.7 mu M, thioridazine had an IC(50) of 1.2 mu M, and trifluoperazine had an IC(50) of 3.8 mu M. Our study demonstrates that some agents used to treat schizophrenia have the ability to inhibit T. gondii proliferation in cell culture.en
dc.description.sponsorshipHarvey W. Peters Research Foundationen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDavid G. Goodwin, Jeannine S. Strobl, and David S. Lindsay (2011). "Evaluation of Five Antischizophrenic Agents Against Toxoplasma gondii in Human Cell Cultures," Journal of Parasitology, Vol. 97, No. 1, pp. 148-151. doi: http://dx.doi.org/10.1645/GE-2536.1en
dc.identifier.doihttps://doi.org/10.1645/ge-2536.1en
dc.identifier.issn0022-3395en
dc.identifier.urihttp://hdl.handle.net/10919/49045en
dc.identifier.urlhttp://www.bioone.org/doi/abs/10.1645/GE-2536.1en
dc.language.isoenen
dc.publisherAmerican Society of Parasitologyen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectPlasmodium-falciparumen
dc.subjectAntipsychotic-drugsen
dc.subjectIn-vitroen
dc.subjectSchizophreniaen
dc.subjectInvasionen
dc.subjectCalciumen
dc.subjectInhibitionen
dc.subjectCalmodulinen
dc.subjectPregnancyen
dc.subjectAciden
dc.subjectParasitologyen
dc.titleEvaluation of Five Antischizophrenic Agents Against Toxoplasma gondii in Human Cell Culturesen
dc.title.serialJournal of Parasitologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
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