History of the Development of Knowledge about the Neuroendocrine Control of Ovulation—Recent Knowledge on the Molecular Background

dc.contributor.authorSzabó, Flóraen
dc.contributor.authorKöves, Katalinen
dc.contributor.authorGál, Leventeen
dc.date.accessioned2024-06-26T13:34:20Zen
dc.date.available2024-06-26T13:34:20Zen
dc.date.issued2024-06-13en
dc.date.updated2024-06-26T13:23:06Zen
dc.description.abstractThe physiology of reproduction has been of interest to researchers for centuries. The purpose of this work is to review the development of our knowledge on the neuroendocrine background of the regulation of ovulation. We first describe the development of the pituitary gland, the structure of the median eminence (ME), the connection between the hypothalamus and the pituitary gland, the ovarian and pituitary hormones involved in ovulation, and the pituitary cell composition. We recall the pioneer physiological and morphological investigations that drove development forward. The description of the supraoptic–paraventricular magnocellular and tuberoinfundibular parvocellular systems and recognizing the role of the hypophysiotropic area were major milestones in understanding the anatomical and physiological basis of reproduction. The discovery of releasing and inhibiting hormones, the significance of pulse and surge generators, the pulsatile secretion of the gonadotropin-releasing hormone (GnRH), and the subsequent pulsatility of luteinizing (LH) and follicle-stimulating hormones (FSH) in the human reproductive physiology were truly transformative. The roles of three critical neuropeptides, kisspeptin (KP), neurokinin B (NKB), and dynorphin (Dy), were also identified. This review also touches on the endocrine background of human infertility and assisted fertilization.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSzabó, F.; Köves, K.; Gál, L. History of the Development of Knowledge about the Neuroendocrine Control of Ovulation—Recent Knowledge on the Molecular Background. Int. J. Mol. Sci. 2024, 25, 6531.en
dc.identifier.doihttps://doi.org/10.3390/ijms25126531en
dc.identifier.urihttps://hdl.handle.net/10919/119518en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectraten
dc.subjecthumanen
dc.subjectGnRHen
dc.subjecthypothalamic regulationen
dc.subjecteffect of illuminationen
dc.titleHistory of the Development of Knowledge about the Neuroendocrine Control of Ovulation—Recent Knowledge on the Molecular Backgrounden
dc.title.serialInternational Journal of Molecular Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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