A Review: competence, compromise, and concomitance-reaction of the host cell to toxoplasma gondii infection and development
dc.contributor.author | Peng, H. J. | en |
dc.contributor.author | Chen, X. G. | en |
dc.contributor.author | Lindsay, David S. | en |
dc.date.accessed | 2014-06-16 | en |
dc.date.accessioned | 2014-06-20T14:13:21Z | en |
dc.date.available | 2014-06-20T14:13:21Z | en |
dc.date.issued | 2011-08 | en |
dc.description.abstract | Toxoplasma gondii is an important zoonotic parasite with a worldwide distribution. It infects about one-third of the world's population, causing serious illness in immunosuppressed individuals, fetuses, and infants. Toxoplasma gondii biology within the host cell includes several important phases: (I) active invasion and establishment of a nonfusogenic parasitophorous vacuole in the host cell, (2) extensive modification of the parasitophorous vacuolar membrane for nutrient acquisition, (3) intracellular proliferation by endodyogeny, (4) egress and invasion of new host cells, and (5) stage conversion from tachyzoite to bradyzoite and establishment of chronic infection. During these processes, T gondii regulates the host cell by modulating morphological, physiological, immunological, genetic, and cellular biological aspects of the host cell. Overall, the infection/development predispositions of T. gondii host cell interactions overtakes the infection resistance aspects. Upon invasion and development, host cells are modulated to keep a delicate balance between facilitating and eliminating the infection. | en |
dc.description.sponsorship | National Scientific Foundation of China 31030066, 81071377 | en |
dc.description.sponsorship | National Special Research Programs for Non-Profit Trades (Agriculture) 200803017 | en |
dc.description.sponsorship | Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme | en |
dc.description.sponsorship | Guangdong Provincial Natural Science Foundation 10151051501000033 | en |
dc.description.sponsorship | Research Fund for the Doctoral Program of Higher Education of China 20104433120014 | en |
dc.description.sponsorship | Guangdong Provincial Medical Research Foundation A2010356 | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.citation | Hong-Juan Peng, Xiao-Guang Chen, and David S. Lindsay (2011). "A Review: Competence, Compromise, and Concomitance-Reaction of the Host Cell To Toxoplasma gondii Infection and Development," Journal of Parasitology, Vol. 97, No. 4, pp. 620-628. doi: http://dx.doi.org/10.1645/GE-2712.1 | en |
dc.identifier.doi | https://doi.org/10.1645/ge-2712.1 | en |
dc.identifier.issn | 0022-3395 | en |
dc.identifier.uri | http://hdl.handle.net/10919/49080 | en |
dc.identifier.url | http://www.bioone.org/doi/abs/10.1645/GE-2712.1 | en |
dc.language.iso | en | en |
dc.publisher | American Society of Parasitology | en |
dc.rights | In Copyright | en |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | en |
dc.subject | parasitophorous vacuole membrane | en |
dc.subject | nf-kappa-b | en |
dc.subject | tissue cyst formation | en |
dc.subject | ifn-gamma | en |
dc.subject | intracellular ca2+ | en |
dc.subject | bradyzoite differentiation | en |
dc.subject | actin | en |
dc.subject | cytoskeleton | en |
dc.subject | human fibroblasts | en |
dc.subject | arachidonic-acid | en |
dc.subject | gene-expression | en |
dc.subject | parasitology | en |
dc.title | A Review: competence, compromise, and concomitance-reaction of the host cell to toxoplasma gondii infection and development | en |
dc.title.serial | Journal of Parasitology | en |
dc.type | Review | en |
dc.type.dcmitype | Text | en |
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