A Review: competence, compromise, and concomitance-reaction of the host cell to toxoplasma gondii infection and development

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dc.contributor.authorPeng, H. J.en
dc.contributor.authorChen, X. G.en
dc.contributor.authorLindsay, David S.en
dc.date.accessed2014-06-16en
dc.date.accessioned2014-06-20T14:13:21Zen
dc.date.available2014-06-20T14:13:21Zen
dc.date.issued2011-08en
dc.description.abstractToxoplasma gondii is an important zoonotic parasite with a worldwide distribution. It infects about one-third of the world's population, causing serious illness in immunosuppressed individuals, fetuses, and infants. Toxoplasma gondii biology within the host cell includes several important phases: (I) active invasion and establishment of a nonfusogenic parasitophorous vacuole in the host cell, (2) extensive modification of the parasitophorous vacuolar membrane for nutrient acquisition, (3) intracellular proliferation by endodyogeny, (4) egress and invasion of new host cells, and (5) stage conversion from tachyzoite to bradyzoite and establishment of chronic infection. During these processes, T gondii regulates the host cell by modulating morphological, physiological, immunological, genetic, and cellular biological aspects of the host cell. Overall, the infection/development predispositions of T. gondii host cell interactions overtakes the infection resistance aspects. Upon invasion and development, host cells are modulated to keep a delicate balance between facilitating and eliminating the infection.en
dc.description.sponsorshipNational Scientific Foundation of China 31030066, 81071377en
dc.description.sponsorshipNational Special Research Programs for Non-Profit Trades (Agriculture) 200803017en
dc.description.sponsorshipGuangdong Province Universities and Colleges Pearl River Scholar Funded Schemeen
dc.description.sponsorshipGuangdong Provincial Natural Science Foundation 10151051501000033en
dc.description.sponsorshipResearch Fund for the Doctoral Program of Higher Education of China 20104433120014en
dc.description.sponsorshipGuangdong Provincial Medical Research Foundation A2010356en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHong-Juan Peng, Xiao-Guang Chen, and David S. Lindsay (2011). "A Review: Competence, Compromise, and Concomitance-Reaction of the Host Cell To Toxoplasma gondii Infection and Development," Journal of Parasitology, Vol. 97, No. 4, pp. 620-628. doi: http://dx.doi.org/10.1645/GE-2712.1en
dc.identifier.doihttps://doi.org/10.1645/ge-2712.1en
dc.identifier.issn0022-3395en
dc.identifier.urihttp://hdl.handle.net/10919/49080en
dc.identifier.urlhttp://www.bioone.org/doi/abs/10.1645/GE-2712.1en
dc.language.isoenen
dc.publisherAmerican Society of Parasitologyen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectparasitophorous vacuole membraneen
dc.subjectnf-kappa-ben
dc.subjecttissue cyst formationen
dc.subjectifn-gammaen
dc.subjectintracellular ca2+en
dc.subjectbradyzoite differentiationen
dc.subjectactinen
dc.subjectcytoskeletonen
dc.subjecthuman fibroblastsen
dc.subjectarachidonic-aciden
dc.subjectgene-expressionen
dc.subjectparasitologyen
dc.titleA Review: competence, compromise, and concomitance-reaction of the host cell to toxoplasma gondii infection and developmenten
dc.title.serialJournal of Parasitologyen
dc.typeReviewen
dc.type.dcmitypeTexten

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