Transfusion with Blood Plasma from Young Mice Affects rTg4510 Transgenic Tau Mice Modeling of Alzheimer's Disease

dc.contributor.authorHernandez, Carlos M.en
dc.contributor.authorBarkey, Rachel E.en
dc.contributor.authorCraven, Kristen M.en
dc.contributor.authorPedemonte, Karin A.en
dc.contributor.authorAlisantosa, Bernadetteen
dc.contributor.authorSanchez, Jonathan O.en
dc.contributor.authorFlinn, Jane M.en
dc.date.accessioned2023-06-27T17:25:26Zen
dc.date.available2023-06-27T17:25:26Zen
dc.date.issued2023-05-23en
dc.date.updated2023-06-27T13:21:40Zen
dc.description.abstractAlzheimer’s disease (AD) is characterized by the buildup of plaques and tangles in the brain. Tangles are formed when the stabilizing protein, tau, becomes hyperphosphorylated and clumps together. There are limited treatments for AD; therefore, the exploration of new treatments is warranted. Previous research showed that plasma transfusion from young donor mice improved spatial memory and increased synaptic proteins in old transgenic APP/PS1 mice, suggesting a remediation of memory and synaptic function. In the current study, plasma was transfused from 2–3-month-old young wildtype mice (WT) to 8-month-old rTg4510 mice expressing human tau (Tau). One week after the transfusions, behavior and tau pathology were examined. We found that Tau mice injected with plasma had lower expression of phosphorylated tau (ptau) in the brain, accompanied by fewer tau tangles in the cortex and CA1 region of the hippocampus and smaller tau tangles in the cortex, when compared to Tau mice injected with saline. Despite no improvement in behavior, the decreased level of ptau and tangles open the door to future studies involving plasma transfusions.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHernandez, C.M.; Barkey, R.E.; Craven, K.M.; Pedemonte, K.A.; Alisantosa, B.; Sanchez, J.O.; Flinn, J.M. Transfusion with Blood Plasma from Young Mice Affects rTg4510 Transgenic Tau Mice Modeling of Alzheimer's Disease. Brain Sci. 2023, 13, 841.en
dc.identifier.doihttps://doi.org/10.3390/brainsci13060841en
dc.identifier.urihttp://hdl.handle.net/10919/115522en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleTransfusion with Blood Plasma from Young Mice Affects rTg4510 Transgenic Tau Mice Modeling of Alzheimer's Diseaseen
dc.title.serialBrain Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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