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The Predictive Value of Plasma Bioactive Lipids on Craving in Human Volunteers With Alcohol Use Disorder

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dc.contributor.authorMiliano, Cristinaen
dc.contributor.authorNatividad, Luis A.en
dc.contributor.authorQuello, Susanen
dc.contributor.authorStoolmiller, Mikeen
dc.contributor.authorGregus, Ann M.en
dc.contributor.authorBuczynski, Matthew W.en
dc.contributor.authorMason, Barbara J.en
dc.date.accessioned2025-02-18T12:58:05Zen
dc.date.available2025-02-18T12:58:05Zen
dc.date.issued2024-07-26en
dc.description.abstractBackground: Alcohol use disorder (AUD) is a chronic relapsing disorder characterized by alcohol seeking and consumption despite negative consequences. Despite the availability of multiple treatments, patients continue to exhibit high relapse rates. Thus, biomarkers that can identify patients at risk for heightened craving are urgently needed. Mounting preclinical and clinical evidence implicates perturbations in bioactive lipid signaling in the neurobiology of craving in AUD. We hypothesize that these lipids are potential biomarkers for predicting alcohol craving in patients with AUD. Methods: This study used archival deidentified clinical data and corresponding plasma specimens from 157 participants in 3 clinical studies of AUD. We evaluated plasma levels of 8 lipid species as predictors of craving in response to in vivo alcohol and affective cues during abstinence. Results: Participants were 109 men and 48 women who met DSM-5 criteria for severe AUD. We found that plasma levels of 12- and 15-HETE, 12/15-lipoxygenase–produced proinflammatory lipids, and palmitoylethanolamide, an anti-inflammatory fatty acid amide hydrolase–regulated lipid metabolite, were differentially correlated with alcohol craving during abstinence, predicting higher craving independent of demographics, alcohol use history, and multiple therapeutic treatments. Conclusions: Our findings highlight the promise of these lipid metabolites as biomarkers of heightened alcohol craving. The results open a novel opportunity for further research and clinical evaluation of these biomarkers to optimize existing treatments and develop new therapeutics for AUD.en
dc.description.versionPublished versionen
dc.format.extent7 page(s)en
dc.format.mimetypeapplication/pdfen
dc.identifierARTN 100368 (Article number)en
dc.identifier.doihttps://doi.org/10.1016/j.bpsgos.2024.100368en
dc.identifier.eissn2667-1743en
dc.identifier.issn2667-1743en
dc.identifier.issue6en
dc.identifier.orcidBuczynski, Matthew [0000-0001-5931-7107]en
dc.identifier.otherPMC11400622en
dc.identifier.otherS2667-1743(24)00081-8 (PII)en
dc.identifier.pmid39282655en
dc.identifier.urihttps://hdl.handle.net/10919/124613en
dc.identifier.volume4en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pubmed/39282655en
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectTRPV1en
dc.subjectAlcohol use disorderen
dc.subjectBiomarkersen
dc.subjectCravingen
dc.subjectEndocannabinoidsen
dc.subjectLipidsen
dc.subjectLipoxygenasesen
dc.titleThe Predictive Value of Plasma Bioactive Lipids on Craving in Human Volunteers With Alcohol Use Disorderen
dc.title.serialBiological Psychiatry: Global Open Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.otherArticleen
dc.type.otherJournalen
dcterms.dateAccepted2024-07-12en
pubs.organisational-groupVirginia Techen
pubs.organisational-groupVirginia Tech/Scienceen
pubs.organisational-groupVirginia Tech/Faculty of Health Sciencesen
pubs.organisational-groupVirginia Tech/All T&R Facultyen
pubs.organisational-groupVirginia Tech/Science/COS T&R Facultyen
pubs.organisational-groupVirginia Tech/Science/School of Neuroscienceen

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