Proteome Analyses of Staphylococcus aureus Biofilm at Elevated Levels of NaCl

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dc.contributor.authorIslam, Nazrulen
dc.contributor.authorRoss, Julia M.en
dc.contributor.authorMarten, Mark R.en
dc.contributor.departmentChemical Engineeringen
dc.date.accessioned2021-02-04T22:12:50Zen
dc.date.available2021-02-04T22:12:50Zen
dc.date.issued2015-10en
dc.date.updated2021-02-04T22:12:47Zen
dc.description.abstractOur studies demonstrate that sodium chloride (NaCl) induces changes in biofilm, mediated by increased production of polysaccharides intercellular adhesion (PIA). We identified 12 proteins that showed higher abundance in increased level of NaCl. This includes one important protein (IsaA) known to be associated with biofilm stability. In addition, we also found higher abundance of a cold shock protein, CspA, at higher NaCl. We have also identified several other proteins that are differentially expressed to the elevated levels of NaCl and mapped them in the regulatory pathways of PIA. The majority of proteins are involved with various aspects bacterial metabolic function. Our results demonstrated that NaCl influences gene regulatory networks controlling exopolysaccharide expression.en
dc.description.versionPublished (Publication status)en
dc.format.mediumPrint-Electronicen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.4172/2327-5073.1000219en
dc.identifier.eissn2327-5073en
dc.identifier.issn2327-5073en
dc.identifier.issue5en
dc.identifier.otherPMC4786021 (pmc)en
dc.identifier.pmid26973848 (pubmed)en
dc.identifier.urihttp://hdl.handle.net/10919/102253en
dc.identifier.volume4en
dc.language.isoenen
dc.publisherOMICS Publishing Groupen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectBiofilmen
dc.subjectElevateden
dc.subjectNaClen
dc.subjectProteomeen
dc.subjectStaphylococcus aureusen
dc.titleProteome Analyses of <i>Staphylococcus aureus</i> Biofilm at Elevated Levels of NaClen
dc.title.serialClinical microbiology (Los Angeles, Calif.)en
dc.typeArticle - Refereeden
dc.type.otherresearch-articleen
dc.type.otherJournal Articleen
pubs.organisational-group/Virginia Tech/Engineeringen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineering/COE T&R Facultyen
pubs.organisational-group/Virginia Tech/Engineering/COE Administrationen
pubs.organisational-group/Virginia Techen

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