Modulation of hepatic PPAR expression during Ft LVS LPS-induced protection from Francisella tularensis LVS infection

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dc.contributor.authorMohapatra, Saroj K.en
dc.contributor.authorCole, Leah E.en
dc.contributor.authorEvans, Cliveen
dc.contributor.authorSobral, Brunoen
dc.contributor.authorBassaganya-Riera, Josepen
dc.contributor.authorHontecillas, Raquelen
dc.contributor.authorVogel, Stefanie N.en
dc.contributor.authorCrasta, Oswald R.en
dc.date.accessioned2012-08-24T11:28:09Zen
dc.date.available2012-08-24T11:28:09Zen
dc.date.issued2010-01-18en
dc.date.updated2012-08-24T11:28:09Zen
dc.description.abstractBackground It has been shown previously that administration of Francisella tularensis (Ft) Live Vaccine Strain (LVS) lipopolysaccharide (LPS) protects mice against subsequent challenge with Ft LVS and blunts the pro-inflammatory cytokine response. Methods To further investigate the molecular mechanisms that underlie Ft LVS LPS-mediated protection, we profiled global hepatic gene expression following Ft LVS LPS or saline pre-treatment and subsequent Ft LVS challenge using Affymetrix arrays. Results A large number of genes (> 3,000) were differentially expressed at 48 hours post-infection. The degree of modulation of inflammatory genes by infection was clearly attenuated by pre-treatment with Ft LVS LPS in the surviving mice. However, Ft LVS LPS alone had a subtle effect on the gene expression profile of the uninfected mice. By employing gene set enrichment analysis, we discovered significant up-regulation of the fatty acid metabolism pathway, which is regulated by peroxisome proliferator activated receptors (PPARs). Conclusions We hypothesize that the LPS-induced blunting of pro-inflammatory response in mouse is, in part, mediated by PPARs (α and Ω).en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBMC Infectious Diseases. 2010 Jan 18;10(1):10en
dc.identifier.doihttps://doi.org/10.1186/1471-2334-10-10en
dc.identifier.urihttp://hdl.handle.net/10919/18848en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderSaroj K Mohapatra et al.; licensee BioMed Central Ltd.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleModulation of hepatic PPAR expression during Ft LVS LPS-induced protection from Francisella tularensis LVS infectionen
dc.title.serialBMC Infectious Diseasesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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