Relationship of plasmids in Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceum

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dc.contributor.authorJucker, Markus Thomasen
dc.contributor.committeechairFalkinham, Joseph O. IIIen
dc.contributor.committeememberBates, Robert C.en
dc.contributor.committeememberBoyle, Stephen M.en
dc.contributor.committeememberJohnson, John L.en
dc.contributor.committeememberLacy, George H.en
dc.contributor.departmentMicrobiologyen
dc.date.accessioned2014-03-14T21:19:13Zen
dc.date.adate2005-09-20en
dc.date.available2014-03-14T21:19:13Zen
dc.date.issued1991-12-05en
dc.date.rdate2005-09-20en
dc.date.sdate2005-09-20en
dc.description.abstractBacteria of the <i>Mycobacterium avium, M. intracellulare, and M. scrofulaceum</i> group (MAIS) are opportunistic human pathogens and widespread in the environment. The first objective of this study was to demonstrate that plasmids from clinical isolates are closely related to plasmids from environmental MAIS isolates. A 12.9 kb plasmid, pVT2, from a clinical <i>M. avium isolate</i>, MDl, was cloned and used a a DNA probe to examine the relationship of MAIS plasmids. The pVT2 probe hybridized with plasmids isolated from MAIS strains from the environment, from patients without AIDS with pulmonary infections, and from AIDS patients with disseminated MAIS infections. Similar results were seen with a second probe derived from pLR 7, a 15.3 kb plasmid from clinical <i>M. intracellulare</i> strain LR 113. The similarity of plasmids from environmental and clinical isolates supports the hypothesis that the environment is a source of MAIS infection in humans.en
dc.description.degreePh. D.en
dc.format.extentix, 89 leavesen
dc.format.mediumBTDen
dc.format.mimetypeapplication/pdfen
dc.identifier.otheretd-09202005-091034en
dc.identifier.sourceurlhttp://scholar.lib.vt.edu/theses/available/etd-09202005-091034/en
dc.identifier.urihttp://hdl.handle.net/10919/39450en
dc.language.isoenen
dc.publisherVirginia Techen
dc.relation.haspartLD5655.V856_1991.J824.pdfen
dc.relation.isformatofOCLC# 26187420en
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.lccLD5655.V856 1991.J824en
dc.subject.lcshMycobacterium diseases -- Epidemiologyen
dc.subject.lcshMycobacterium intracellulare -- Geneticsen
dc.subject.lcshPlasmids -- Geneticsen
dc.titleRelationship of plasmids in Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium scrofulaceumen
dc.typeDissertationen
dc.type.dcmitypeTexten
thesis.degree.disciplineMicrobiologyen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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