The feather pattern autosomal barring in chicken is strongly associated with segregation at the MC1R locus

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dc.contributor.authorThalmann, Doreen Schwochowen
dc.contributor.authorBornelov, Susanneen
dc.contributor.authorJiang, Tingxinen
dc.contributor.authorLi, Jingyien
dc.contributor.authorGourichon, Daviden
dc.contributor.authorBed'Hom, Bertranden
dc.contributor.authorDorshorst, Benjamin J.en
dc.contributor.authorChuong, Cheng-Mingen
dc.contributor.authorTixier-Boichard, Micheleen
dc.contributor.authorAndersson, Leifen
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2021-07-28T18:14:03Zen
dc.date.available2021-07-28T18:14:03Zen
dc.date.issued2021-04-01en
dc.description.abstractColor patterns within individual feathers are common in birds but little is known about the genetic mechanisms causing such patterns. Here, we investigate the genetic basis for autosomal barring in chicken, a horizontal striping pattern on individual feathers. Using an informative backcross, we demonstrate that the MC1R locus is strongly associated with this phenotype. A deletion at SOX10, underlying the dark brown phenotype on its own, affects the manifestation of the barring pattern. The coding variant L133Q in MC1R is the most likely causal mutation for autosomal barring in this pedigree. Furthermore, a genetic screen across six different breeds showing different patterning phenotypes revealed that the most striking shared characteristics among these breeds were that they all carried the MC1R alleles Birchen or brown. Our data suggest that the presence of activating MC1R mutations enhancing pigment synthesis is an important mechanism underlying pigmentation patterns on individual feathers in chicken. We propose that MC1R and its antagonist ASIP play a critical role for determining within-feather pigmentation patterns in birds by acting as activator and inhibitor possibly in a Turing reaction-diffusion model.en
dc.description.notesVetenskapsradet, Grant/Award Number: Radsprofessur; Knut och Alice Wallenbergs Stiftelse, Grant/Award Number: KAW scholar; Foundation for the National Institutes of Health, Grant/Award Number: AR060306en
dc.description.sponsorshipVetenskapsradetSwedish Research Council; Knut och Alice Wallenbergs StiftelseKnut & Alice Wallenberg Foundation; Foundation for the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [AR060306]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/pcmr.12975en
dc.identifier.eissn1755-148Xen
dc.identifier.issn1755-1471en
dc.identifier.pmid33793042en
dc.identifier.urihttp://hdl.handle.net/10919/104427en
dc.language.isoenen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectchickenen
dc.subjectfeather patterningen
dc.subjectgeneticsen
dc.subjectMC1Ren
dc.subjectpigmentationen
dc.subjectSOX10en
dc.titleThe feather pattern autosomal barring in chicken is strongly associated with segregation at the MC1R locusen
dc.title.serialPigment Cell & Melanoma Researchen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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