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Mitochondrial alteration in type 2 diabetes and obesity

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dc.contributor.authorCheng, Zhiyongen
dc.contributor.authorAlmeida, Fabio A.en
dc.contributor.departmentHuman Nutrition, Foods, and Exerciseen
dc.date.accessioned2017-02-15T19:12:03Zen
dc.date.available2017-02-15T19:12:03Zen
dc.date.issued2014-03-15en
dc.description.abstractThe growing epidemic of type 2 diabetes mellitus (T2DM) and obesity is largely attributed to the current lifestyle of over-consumption and physical inactivity. As the primary platform controlling metabolic and energy homeostasis, mitochondria show aberrant changes in T2DM and obese subjects. While the underlying mechanism is under extensive investigation, epigenetic regulation is now emerging to play an important role in mitochondrial biogenesis, function, and dynamics. In line with lifestyle modifications preventing mitochondrial alterations and metabolic disorders, exercise has been shown to change DNA methylation of the promoter of PGC1α to favor gene expression responsible for mitochondrial biogenesis and function. In this article we discuss the epigenetic mechanism of mitochondrial alteration in T2DM and obesity, and the effects of lifestyle on epigenetic regulation. Future studies designed to further explore and integrate the epigenetic mechanisms with lifestyle modification may lead to interdisciplinary interventions and novel preventive options for mitochondrial alteration and metabolic disorders.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.4161/cc.28189en
dc.identifier.issue6en
dc.identifier.urihttp://hdl.handle.net/10919/75046en
dc.identifier.volume13en
dc.language.isoenen
dc.publisherLandes Bioscienceen
dc.rightsCreative Commons Attribution-NonCommercial 3.0 United Statesen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/en
dc.subjectmitochondrial alterationen
dc.subjectepigeneticen
dc.subjecttype 2 diabetesen
dc.subjectObesityen
dc.subjectlifestyleen
dc.titleMitochondrial alteration in type 2 diabetes and obesityen
dc.title.serialCell Cycleen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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