Cell cycle regulation by feed-forward loops coupling transcription and phosphorylation

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dc.contributor.authorCsikasz-Nagy, Attilaen
dc.contributor.authorKapuy, Orsolyaen
dc.contributor.authorToth, Attilaen
dc.contributor.authorPal, Csabaen
dc.contributor.authorJensen, Lars Juhlen
dc.contributor.authorUhlmann, Franken
dc.contributor.authorTyson, John J.en
dc.contributor.authorNovak, Belaen
dc.contributor.departmentBiological Sciencesen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2016-12-09T21:35:02Zen
dc.date.available2016-12-09T21:35:02Zen
dc.date.issued2009-01-01en
dc.description.abstractThe eukaryotic cell cycle requires precise temporal coordination of the activities of hundreds of ‘executor’ proteins (EPs) involved in cell growth and division. Cyclin-dependent protein kinases (Cdks) play central roles in regulating the production, activation, inactivation and destruction of these EPs. From genome-scale data sets of budding yeast, we identify 126 EPs that are regulated by Cdk1 both through direct phosphorylation of the EP and through phosphorylation of the transcription factors that control expression of the EP, so that each of these EPs is regulated by a feed-forward loop (FFL) from Cdk1. By mathematical modelling, we show that such FFLs can activate EPs at different phases of the cell cycle depending of the effective signs (+ or -) of the regulatory steps of the FFL.We provide several case studies of EPs that are controlled by FFLs exactly as our models predict. The signal-transduction properties of FFLs allow one (or a few) Cdk signal(s) to drive a host of cell cycle responses in correct temporal sequence.en
dc.description.versionPublished versionen
dc.format.extent? - ? (6) page(s)en
dc.identifier.doihttps://doi.org/10.1038/msb.2008.73en
dc.identifier.issn1744-4292en
dc.identifier.urihttp://hdl.handle.net/10919/73632en
dc.identifier.volume5en
dc.languageEnglishen
dc.publisherNature Publishing Groupen
dc.relation.urihttp://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000263167600006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=930d57c9ac61a043676db62af60056c1en
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 3.0 Unporteden
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en
dc.subjectBiochemistry & Molecular Biologyen
dc.subjectbudding yeasten
dc.subjectcell cycleen
dc.subjectDNA replicationen
dc.subjectfeed-forward loopen
dc.subjectCDK-DEPENDENT PHOSPHORYLATIONen
dc.subjectKINASE INHIBITOR P40(SIC1)en
dc.subjectSACCHAROMYCES-CEREVISIAEen
dc.subjectBUDDING YEASTen
dc.subjectDNA-REPLICATIONen
dc.subjectPOSITIVE FEEDBACKen
dc.subjectGENESen
dc.subjectSLD2en
dc.subjectTRANSITIONSen
dc.subjectNETWORKSen
dc.titleCell cycle regulation by feed-forward loops coupling transcription and phosphorylationen
dc.title.serialMolecular Systems Biologyen
dc.typeArticle - Refereeden
pubs.organisational-group/Virginia Techen
pubs.organisational-group/Virginia Tech/All T&R Facultyen
pubs.organisational-group/Virginia Tech/Faculty of Health Sciencesen
pubs.organisational-group/Virginia Tech/Scienceen
pubs.organisational-group/Virginia Tech/Science/Biological Sciencesen
pubs.organisational-group/Virginia Tech/Science/COS T&R Facultyen
pubs.organisational-group/Virginia Tech/University Distinguished Professorsen

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