Toll-Interacting Protein Regulation of Low-grade Non-resolving Inflammation

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dc.contributor.authorKowalski, Elizabeth Ashleyen
dc.contributor.committeechairLi, Liwuen
dc.contributor.committeememberBevan, David R.en
dc.contributor.committeememberHelm, Richard F.en
dc.contributor.committeememberXu, Binen
dc.contributor.departmentBiochemistryen
dc.date.accessioned2017-07-14T08:00:18Zen
dc.date.available2017-07-14T08:00:18Zen
dc.date.issued2017-07-13en
dc.description.abstractInnate leukocytes manifest dynamic and distinct inflammatory responses upon challenges with rising dosages of pathogen associated molecular pattern molecules (PAMPs) such as lipopolysaccharide (LPS). To differentiate signal strengths, innate leukocytes may utilize distinct intra-cellular signaling circuitries modulated by adaptor molecules. Toll-interacting protein (Tollip) is one of the critical adaptor molecules in Toll-like receptor 4 (TLR4) signaling and potentially playing key roles in modulating the dynamic adaptation of innate leukocytes to varying dosages of external stimulants. While Tollip may serve as a negative regulator of NFkB signaling pathway in cells challenged with higher dosages of LPS, it acts as a positive regulator for low-grade chronic inflammation in leukocytes programmed by subclinical low-dosages of LPS. We aim to show recent progress in our understanding of complex innate leukocyte dynamics and its relevance in the pathogenesis of resolving versus non-resolving chronic inflammatory diseases.en
dc.description.degreePh. D.en
dc.format.mediumETDen
dc.identifier.othervt_gsexam:11144en
dc.identifier.urihttp://hdl.handle.net/10919/78340en
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectLow-grade inflammationen
dc.subjectInnate Immunityen
dc.subjectToll-interacting proteinen
dc.subjectTLR4en
dc.subjectImmunologyen
dc.titleToll-Interacting Protein Regulation of Low-grade Non-resolving Inflammationen
dc.typeDissertationen
thesis.degree.disciplineBiochemistryen
thesis.degree.grantorVirginia Polytechnic Institute and State Universityen
thesis.degree.leveldoctoralen
thesis.degree.namePh. D.en

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