Design and Modification of Half-Sandwich Ir(III), Rh(III), and Ru(II) Amino Acid Complexes for Application in Asymmetric Transfer Hydrogenation Reactions

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Virginia Tech

This dissertation describes the design and synthesis of a series of half-sandwich amino acid complexes of the form), (aa = α-amino carboxylate), and their utility as asymmetric transfer hydrogenation catalysts of ketones. Variation of the metal center, the n-ring, and the aa was used to tune these systems for specific sets of ketones. Upon reaction with homochiral]s, the ligand environment in all of these complexes is pseudotetrahedral, leading to stereogenic metal ions (SM, RM). The addition of another stereogenic center from the amino acid ligand (the carbon, RC or SC;glycine) gives rise to two pairs of diastereomeric complexes.

asymmetric transfer hydrogenation, amino acid, half-sandwich complex, iridium, rhodium, ruthenium, tetramethylcyclopentadiene, arene, solvent effects