Theoretical Investigation of Biological Networks Coupled via Bottlenecks in Enzymatic Processing

dc.contributor.authorOgle, Curtis Tayloren
dc.contributor.committeechairMather, Williamen
dc.contributor.committeememberCheng, Shengfengen
dc.contributor.committeememberPleimling, Michel J.en
dc.contributor.committeememberHuber, Patricken
dc.description.abstractCell biology is a branch of science with a seemingly infinite abundance of interesting phenomena which are essential to our understanding of life and which may potentially drive the development of technology that improves our lives. Among the open ended questions within the field, an understanding of how gene networks are affected by limited cellular components is both broad and rich with interest. Common to all cellular systems are enzymes which perform many tasks within cells without which organisms could not remain healthy. Here are presented several explorations of enzymatic processing as well as a tool constructed for this purpose. More specifically, these works consider the effect of coupling of gene networks via competition for enzymes found within the cell. It is shown that a limitation on the number of available enzymes permits the formation of bottlenecks which drastically affect molecular dynamics within cells. These effects potentially afford cell behaviors that in part explain the impressive robustness of life to constantly fluctuating environments.en
dc.description.degreePh. D.en
dc.publisherVirginia Techen
dc.rightsIn Copyrighten
dc.subjectPost-translational Couplingen
dc.subjectToxin-antitoxin Modulesen
dc.subjectEnzymatic Degradationen
dc.subjectQueueing Theoryen
dc.titleTheoretical Investigation of Biological Networks Coupled via Bottlenecks in Enzymatic Processingen
dc.typeDissertationen Polytechnic Institute and State Universityen D.en


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