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A cis-Regulatory Mutation of PDSS2 Causes Silky-Feather in Chickens

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dc.contributor.authorFeng, Chungangen
dc.contributor.authorGao, Yuen
dc.contributor.authorDorshorst, Benjamin J.en
dc.contributor.authorSong, Chien
dc.contributor.authorGu, Xiaorongen
dc.contributor.authorLi, Qingyuanen
dc.contributor.authorLi, Jinxiuen
dc.contributor.authorLiu, Tongxinen
dc.contributor.authorRubin, Carl-Johanen
dc.contributor.authorZhao, Yiqiangen
dc.contributor.authorWang, Yanqiangen
dc.contributor.authorFei, Jingen
dc.contributor.authorLi, Huifangen
dc.contributor.authorChen, Kuanweien
dc.contributor.authorQu, Haoen
dc.contributor.authorShu, Dingmingen
dc.contributor.authorAshwell, Christopher M.en
dc.contributor.authorDa, Yangen
dc.contributor.authorAndersson, Leifen
dc.contributor.authorHu, Xiaoxiangen
dc.contributor.authorLi, Ningen
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.date.accessioned2019-10-22T17:51:30Zen
dc.date.available2019-10-22T17:51:30Zen
dc.date.issued2014-08en
dc.description.abstractSilky-feather has been selected and fixed in some breeds due to its unique appearance. This phenotype is caused by a single recessive gene (hookless, h). Here we map the silky-feather locus to chromosome 3 by linkage analysis and subsequently fine-map it to an 18.9 kb interval using the identical by descent (IBD) method. Further analysis reveals that a C to G transversion located upstream of the prenyl (decaprenyl) diphosphate synthase, subunit 2 (PDSS2) gene is causing silky-feather. All silky-feather birds are homozygous for the G allele. The silky-feather mutation significantly decreases the expression of PDSS2 during feather development in vivo. Consistent with the regulatory effect, the C to G transversion is shown to remarkably reduce PDSS2 promoter activity in vitro. We report a new example of feather structure variation associated with a spontaneous mutation and provide new insight into the PDSS2 function.en
dc.description.notesThis work was supported by grants from the National High Technology Research and Development Program of China (2011AA100301), National Key Technologies R&D Program (2011BAD28B03), Key Technology Research and Development Program of Guangdong Emerging Strategic Industries (2012A020800005) and 948 Program of the Ministry of Agriculture of China (2012-G1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.description.sponsorshipNational High Technology Research and Development Program of ChinaNational High Technology Research and Development Program of China [2011AA100301]; National Key Technologies RD ProgramNational Key Technology R&D Program [2011BAD28B03]; Key Technology Research and Development Program of Guangdong Emerging Strategic Industries [2012A020800005]; 948 Program of the Ministry of Agriculture of China [2012-G1]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pgen.1004576en
dc.identifier.issn1553-7404en
dc.identifier.issue8en
dc.identifier.othere1004576en
dc.identifier.pmid25166907en
dc.identifier.urihttp://hdl.handle.net/10919/95025en
dc.identifier.volume10en
dc.language.isoenen
dc.publisherPLoSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleA cis-Regulatory Mutation of PDSS2 Causes Silky-Feather in Chickensen
dc.title.serialPLOS Geneticsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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