Horses experimentally infected with sarcocystis neurona develop altered immune responses in vitro

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dc.contributor.authorWitonsky, Sharon G.en
dc.contributor.authorEllison, Siobhanen
dc.contributor.authorYang, Jibingen
dc.contributor.authorGogal, Robert M.en
dc.contributor.authorLawler, Heatheren
dc.contributor.authorSuzuki, Yasuhiroen
dc.contributor.authorSriranganathan, Nammalwaren
dc.contributor.authorAndrews, Frank M.en
dc.contributor.authorWard, Danielen
dc.contributor.authorLindsay, David S.en
dc.date.accessed2014-06-16en
dc.date.accessioned2014-06-20T14:13:15Zen
dc.date.available2014-06-20T14:13:15Zen
dc.date.issued2008-10en
dc.description.abstractEquine protozoal myeloencephalitis (EPM) due to Sarcocystis neurona infection is I of the most common neurologic diseases in horses in the United States. The mechanisms by which most horses resist disease, as well as the possible mechanisms by which the immune system may be suppressed in horses that develop EPM, are not known. Therefore, the objectives of this study were to determine whether horses experimentally infected with S. neurona developed suppressed immune responses. Thirteen horses that were negative for S. neurona antibodies in serum and cerebrospinal fluid (CSF) were randomly assigned to control (n = 5) or infected (n = 8) treatment groups. Neurologic exams and cerebrospinal fluid analyses were performed prior to, and following, S. neurona infection. Prior to, and at multiple time points following infection, immune parameters were determined. All 8 S. neurona-infected horses developed clinical signs consistent with EPM, and had S. neurona antibodies in the serum and CSF Both infected and control horses had increased percentages (P < 0.05) of B cells at 28 clays postinfection. Infected horses had significantly decreased (P < 0.05) proliferation responses as measured by thymidine incorporation to nonspecific mitogens phorbol myristate acetate (PMA) and ionomycin (I) as soon as 2 days postinfection.en
dc.description.sponsorshipVirginia Techen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSharon G. Witonsky, Siobhan Ellison, Jibing Yang, Robert M. Gogal, Heather Lawler, Yasuhiro Suzuki, Namalwar Sriranganathan, Frank Andrews, Daniel Ward, and David S. Lindsay (2008). "Horses Experimentally Infected with Sarcocystis neurona Develop Altered Immune Responses In Vitro," Journal of Parasitology, Vol. 94, No. 5, pp. 1047-1054. doi: http://dx.doi.org/10.1645/GE-1441.1en
dc.identifier.doihttps://doi.org/10.1645/ge-1441.1en
dc.identifier.issn0022-3395en
dc.identifier.urihttp://hdl.handle.net/10919/49051en
dc.identifier.urlhttp://www.bioone.org/doi/abs/10.1645/GE-1441.1en
dc.language.isoenen
dc.publisherAmerican Society of Parasitologyen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectequine protozoal myeloencephalitisen
dc.subjectnf-kappa-ben
dc.subjecttoxoplasma-gondiien
dc.subjectcerebral toxoplasmosisen
dc.subjectt-lymphocytesen
dc.subjectmiceen
dc.subjectcellsen
dc.subjectcalciumen
dc.subjectmerozoitesen
dc.subjectexpressionen
dc.subjectparasitologyen
dc.titleHorses experimentally infected with sarcocystis neurona develop altered immune responses in vitroen
dc.title.serialJournal of Parasitologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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