Designing Patient-Driven, Tissue-Engineered Models of Primary and Metastatic Breast Cancer

dc.contributor.authorBeeghly, Garrett F.en
dc.contributor.authorThomas, Candaceen
dc.contributor.authorYuan, Jessica X.en
dc.contributor.authorHarris, Alexandra R.en
dc.contributor.authorMunson, Jennifer M.en
dc.date.accessioned2022-01-21T15:10:12Zen
dc.date.available2022-01-21T15:10:12Zen
dc.date.issued2022-01-18en
dc.date.updated2022-01-20T15:24:38Zen
dc.description.abstractThe rising survival rate for early-stage breast cancer in the United States has created an expanding population of women in remission at risk for distant recurrence, with metastatic spread to the brain demonstrating an especially poor prognosis. The current standard of care for breast cancer brain metastases is not well defined or differentiated from the treatment of brain metastases from other primary sites. Here, we present tissue-engineered models of the primary and brain metastatic breast cancer microenvironments informed by analysis of patient tumor resections. We find that metastatic resections demonstrate distinct cellular and matrix components compared with primary resections or non-cancerous controls. Using our model systems, we find that the observed deposition of collagen I after metastasis to the brain may enhance breast cancer invasion. Future optimization of these models will present a novel platform to examine tumor-stroma interactions and screen therapeutics for the management of metastatic breast cancer.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationBeeghly, G.F.; Thomas, C.; Yuan, J.X.; Harris, A.R.; Munson, J.M. Designing Patient-Driven, Tissue-Engineered Models of Primary and Metastatic Breast Cancer. Bioengineering 2022, 9, 44.en
dc.identifier.doihttps://doi.org/10.3390/bioengineering9020044en
dc.identifier.urihttp://hdl.handle.net/10919/107841en
dc.language.isoenen
dc.publisherMDPIen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleDesigning Patient-Driven, Tissue-Engineered Models of Primary and Metastatic Breast Canceren
dc.title.serialBioengineeringen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
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