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Dynamics of Small Non-coding RNA Profiles and the Intestinal Microbiome of High and Low Weight Chickens

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dc.contributor.authorZhou, Haoen
dc.contributor.authorYang, Lingyuen
dc.contributor.authorDing, Jinmeien
dc.contributor.authorXu, Keen
dc.contributor.authorLiu, Jiajiaen
dc.contributor.authorZhu, Wenqien
dc.contributor.authorZhu, Jianshenen
dc.contributor.authorHe, Chuanen
dc.contributor.authorHan, Chengxiaoen
dc.contributor.authorQin, Chaoen
dc.contributor.authorLuo, Huaixien
dc.contributor.authorChen, Kangchunen
dc.contributor.authorZheng, Yumingen
dc.contributor.authorHonaker, Christa F.en
dc.contributor.authorZhang, Yanen
dc.contributor.authorSiegel, Paul B.en
dc.contributor.authorMeng, Heen
dc.date.accessioned2022-11-10T15:05:59Zen
dc.date.available2022-11-10T15:05:59Zen
dc.date.issued2022-06-30en
dc.description.abstractThe host and its symbiotic bacteria form a biological entity, holobiont, in which they share a dynamic connection characterized by symbiosis, co-metabolism, and coevolution. However, how these collaborative relationships were maintained over evolutionary time remains unclear. In this research, the small non-coding RNA (sncRNA) profiles of cecum and their bacteria contents were measured from lines of chickens that have undergone long-term selection for high (HWS) or low (LWS) 56-day body weight. The results from these lines that originated from a common founder population and maintained under the same husbandry showed an association between host intestinal sncRNA expression profile (miRNA, lncRNA fragment, mRNA fragment, snoRNA, and snRNA) and intestinal microbiota. Correlation analyses suggested that some central miRNAs and mRNA fragments had interactions with the abundance of intestinal microbial species and microbiota functions. miR-6622-3p, a significantly differentially expressed (DE) miRNA was correlated with a body weight gain related bacterium, Alistipes putredinis. Our results showed that host sncRNAs may be mediators of interaction between the host and its intestinal microbiome. This provides additional clue for holobiont concepts.en
dc.description.notesFunding This work was supported by the National Natural Science Foundation of China 31572384 (HM).en
dc.description.sponsorshipNational Natural Science Foundation of China [31572384]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fmicb.2022.916280en
dc.identifier.eissn1664-302Xen
dc.identifier.other916280en
dc.identifier.pmid35847106en
dc.identifier.urihttp://hdl.handle.net/10919/112553en
dc.identifier.volume13en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectsmall non-coding RNAen
dc.subjectintestinal bacteriaen
dc.subjectco-evolutionen
dc.subjecthost-microbiota interactionsen
dc.subjectcecumen
dc.subjectchickenen
dc.titleDynamics of Small Non-coding RNA Profiles and the Intestinal Microbiome of High and Low Weight Chickensen
dc.title.serialFrontiers in Microbiologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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